基本信息:
- 专利标题： ANOIKIS RESISTANT PLACENTAL STEM CELLS AND USES THEREOF
- 专利标题（中）：抗敏耐药细胞干细胞及其用途
- 申请号：PCT/US2013/074892 申请日：2013-12-13
- 公开(公告)号：WO2014093753A1 公开(公告)日：2014-06-19
- 发明人： ZHANG, Xiaokui , ABBOT, Stewart , VOSKINARIAN-BERSE, Vanessa
- 申请人： ANTHROGENESIS CORPORATION
- 申请人地址： 33 Technology Drive Warren, NJ 07059 US
- 专利权人： ANTHROGENESIS CORPORATION
- 当前专利权人： ANTHROGENESIS CORPORATION
- 当前专利权人地址： 33 Technology Drive Warren, NJ 07059 US
- 代理机构： GEORGE, Nikolaos, C. et al.
- 优先权： US61/737,498 20121214
- 主分类号： A01N63/00
- IPC分类号： A01N63/00 ; C12N15/00 ; C12N5/02
摘要：
Anoikis resistant placental stem cells ( arPSCs) with increased survival in low-attachment environments, and thus can advantageously be used, e.g., in therapies based on their ability to persist for longer durations of time in an unattached state. A method of modifying placental stem cells to make them anoikis resistant, comprising contacting the placental stem cells with an effective amount of modulatory RNA molecules, such that one or more genes associated with anoikis of the placental stem cells is inhibited. Further discloses are genes that are associated with anoikis for modulation.
摘要（中）：
在低附着环境中具有增加的存活率的耐酸性胎盘干细胞（arPSC），因此可以有利地用于例如基于在未附着状态下持续较长持续时间的能力的治疗。 一种修饰胎盘干细胞以使其具有抗氧化性的方法，包括使胎盘干细胞与有效量的调节性RNA分子接触，使得与胎盘干细胞的脱落相关联的一个或多个基因被抑制。 进一步公开的是与用于调制的厌食相关的基因。