基本信息:
- 专利标题： PURINE INHIBITORS OF HUMAN PHOSPHATIDYLINOSITOL 3-KINASE DELTA
- 专利标题（中）：人类磷脂酰肌醇三激酶三磷酸抑制剂
- 申请号：PCT/CN2013/001395 申请日：2013-11-15
- 公开(公告)号：WO2014075393A1 公开(公告)日：2014-05-22
- 发明人： ACHAB, Abdelghani Abe , ALTMAN, Michael D. , DENG, Yongqi , KATTAR, Solomon , KATZ, Jason D. , METHOT, Joey L. , ZHOU, Hua , MCGOWAN, Meredeth , CHRISTOPHER, Matthew P. , GARCIA, Yudith , ANTHONY, Neville John , FRADERA LLINAS, Francesc Xavier , YANG, Liping , MU, Changwei , WANG, Xiaona , SHI, Feng , YE, Baijun , ZHANG, Sixing , ZHAO, Xiaoli , ZHANG, Rong , FONG, Kin Chiu , LENG, Xiansheng
- 申请人： MERCK SHARP & DOHME CORP. , ACHAB, Abdelghani Abe , ALTMAN, Michael D. , DENG, Yongqi , KATTAR, Solomon , KATZ, Jason D. , METHOT, Joey L. , ZHOU, Hua , MCGOWAN, Meredeth , CHRISTOPHER, Matthew P. , GARCIA, Yudith , ANTHONY, Neville John , FRADERA LLINAS, Francesc Xavier , YANG, Liping , MU, Changwei , WANG, Xiaona , SHI, Feng , YE, Baijun , ZHANG, Sixing , ZHAO, Xiaoli , ZHANG, Rong , FONG, Kin Chiu , LENG, Xiansheng
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 专利权人： MERCK SHARP & DOHME CORP.,ACHAB, Abdelghani Abe,ALTMAN, Michael D.,DENG, Yongqi,KATTAR, Solomon,KATZ, Jason D.,METHOT, Joey L.,ZHOU, Hua,MCGOWAN, Meredeth,CHRISTOPHER, Matthew P.,GARCIA, Yudith,ANTHONY, Neville John,FRADERA LLINAS, Francesc Xavier,YANG, Liping,MU, Changwei,WANG, Xiaona,SHI, Feng,YE, Baijun,ZHANG, Sixing,ZHAO, Xiaoli,ZHANG, Rong,FONG, Kin Chiu,LENG, Xiansheng
- 当前专利权人： MERCK SHARP & DOHME CORP.,ACHAB, Abdelghani Abe,ALTMAN, Michael D.,DENG, Yongqi,KATTAR, Solomon,KATZ, Jason D.,METHOT, Joey L.,ZHOU, Hua,MCGOWAN, Meredeth,CHRISTOPHER, Matthew P.,GARCIA, Yudith,ANTHONY, Neville John,FRADERA LLINAS, Francesc Xavier,YANG, Liping,MU, Changwei,WANG, Xiaona,SHI, Feng,YE, Baijun,ZHANG, Sixing,ZHAO, Xiaoli,ZHANG, Rong,FONG, Kin Chiu,LENG, Xiansheng
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065 US
- 代理机构： LIU, SHEN & ASSOCIATES
- 优先权： US61/727,392 20121116
- 主分类号： C07D473/34
- IPC分类号： C07D473/34 ; A61K31/52 ; A61P19/02 ; A61P11/00 ; A61P37/00 ; A61P35/00
摘要：
The instant invention provides compounds of formula I which are PI3K-delta inhibitors, and as such are useful for the treatment of PI3K-delta-mediated diseases such as inflamation, asthma, COPD and cancer.
摘要（中）：
本发明提供了作为PI3K-δ抑制剂的式I化合物，因此可用于治疗PI3K-δ介导的疾病如炎症，哮喘，COPD和癌症。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D473/00 | 含嘌呤环系的杂环化合物 |
| --------C07D473/02 | .有氧、硫或氮原子直接连在位置2和6 |
| ----------C07D473/28 | ..氧原子 |
| ------------C07D473/34 | ...连在位置6，例如6-氨基嘌呤 |