发明申请
WO2014028511A1 ATTENUATED LIVE VACCINE FOR CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS AND ERVE VIRUS
审中-公开
基本信息:
- 专利标题： ATTENUATED LIVE VACCINE FOR CRIMEAN-CONGO HEMORRHAGIC FEVER VIRUS AND ERVE VIRUS
- 专利标题（中）：用于克里米亚高血压病毒性病毒和病毒的灭活活疫苗
- 申请号：PCT/US2013/054760 申请日：2013-08-13
- 公开(公告)号：WO2014028511A1 公开(公告)日：2014-02-20
- 发明人： BERGERON, Eric , PEGAN, Scott Dusan , NICHOL, Stuart T. , DEATON, Michelle Kay
- 申请人： COLORADO SEMINARY WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： Office of Technology Transfer 2199 S. University Blvd., 222 MRB Denver, Colorado 80208 US
- 专利权人： COLORADO SEMINARY WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： COLORADO SEMINARY WHICH OWNS AND OPERATES THE UNIVERSITY OF DENVER,THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： Office of Technology Transfer 2199 S. University Blvd., 222 MRB Denver, Colorado 80208 US
- 代理机构： SCHIFF, Michael et al.
- 优先权： US61/683,132 20120814; US13/829,105 20130314
- 主分类号： A61K39/12
- IPC分类号： A61K39/12 ; C12N7/00 ; C12N7/04
摘要：
The genetically modified nairoviruses of this invention possesses a viral ovarian tumor protease with decreased ability to remove ubiquitin (Ub) and ISG15 tags that the human organism uses to label proteins for removal. Exemplary are Crimean-Congo hemorrhagic fever virus and Erve virus. Unlike complete knockout strains, the modified virus retains enough activity for replication in a human cell line. This creates an immunogenic and non-pathogenic virus that can be used as an effective live vaccine agent for prophylaxis and treatment.
摘要（中）：
本发明的遗传修饰的纳维克病毒具有病毒性卵巢肿瘤蛋白酶，其具有降低人类生物体用于标记蛋白质去除的泛素（Ub）和ISG15标签的能力降低的能力。 示例是克里米亚 - 刚果出血热病毒和埃尔韦病毒。 与完全敲除菌株不同，经修饰的病毒在人细胞系中保留足够的活性用于复制。 这产生可用作预防和治疗的有效活疫苗剂的免疫原性和非致病性病毒。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/12 | .病毒性抗原 |