基本信息:
- 专利标题： TrkA KINASE INHIBITORS, COMPOSITIONS AND METHODS THEREOF
- 专利标题（中）：TrkA激酶抑制剂，其组合物及其方法
- 申请号：PCT/US2013/041492 申请日：2013-05-17
- 公开(公告)号：WO2013176970A1 公开(公告)日：2013-11-28
- 发明人： STACHEL, Shawn, J. , EGBERTSON, Melissa , BRNARDIC, Edward , JONES, Kristen , SANDERS, John, M. , HENZE, Darrell, A.
- 申请人： MERCK SHARP & DOHME CORP. , STACHEL, Shawn, J. , EGBERTSON, Melissa , BRNARDIC, Edward , JONES, Kristen , SANDERS, John, M. , HENZE, Darrell, A.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,STACHEL, Shawn, J.,EGBERTSON, Melissa,BRNARDIC, Edward,JONES, Kristen,SANDERS, John, M.,HENZE, Darrell, A.
- 当前专利权人： MERCK SHARP & DOHME CORP.,STACHEL, Shawn, J.,EGBERTSON, Melissa,BRNARDIC, Edward,JONES, Kristen,SANDERS, John, M.,HENZE, Darrell, A.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： US61/650,019 20120522
- 主分类号： A01N47/28
- IPC分类号： A01N47/28 ; A61K31/17
摘要：
The present invention is directed to benzyl urea compounds, which are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and hence may be useful in the treatment of pain, inflammation, cancer, restenosis, atherosclerosis, psoriasis, thrombosis, a disease, disorder, injury, or malfunction relating to dysmyelination or demyelination or a disease or disorder associated with abnormal activities of nerve growth factor (NGF) receptor Trk-A, Trk-B and/or Trk-C.
摘要（中）：
本发明涉及苄基脲化合物，其是原肌球蛋白相关激酶（Trk）家族蛋白激酶抑制剂，因此可用于治疗疼痛，炎症，癌症，再狭窄，动脉粥样硬化，牛皮癣，血栓形成，疾病， 与神经生长因子（NGF）受体Trk-A，Trk-B和/或Trk-C的异常活动相关的疾病或障碍或与脱髓鞘或脱髓鞘相关的疾病，损伤或功能障碍。