发明申请
WO2013154728A1 GENETICALLY STABLE LIVE ATTENUATED RESPIRATORY SYNCYTIAL VIRUS VACCINE AND ITS PRODUCTION
审中-公开
基本信息:
- 专利标题： GENETICALLY STABLE LIVE ATTENUATED RESPIRATORY SYNCYTIAL VIRUS VACCINE AND ITS PRODUCTION
- 专利标题（中）：基因稳定的活体灭活呼吸道病毒疫苗及其生产
- 申请号：PCT/US2013/030836 申请日：2013-03-13
- 公开(公告)号：WO2013154728A1 公开(公告)日：2013-10-17
- 发明人： COLLINS, Peter, L. , LUONGO, Cindy, L. , BUCHHOLZ, Ursula, J. , MURPHY, Brian, R.
- 申请人： THE UNITED STATES OF AMERICA , as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 申请人地址： Office of Technology Transfer, National Institutes of Health 6011 Executive Boulevard, Suite 325, MSC 7660 US
- 专利权人： THE UNITED STATES OF AMERICA , as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人： THE UNITED STATES OF AMERICA , as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
- 当前专利权人地址： Office of Technology Transfer, National Institutes of Health 6011 Executive Boulevard, Suite 325, MSC 7660 US
- 代理机构： CALDWELL, John W. et al.
- 优先权： US61/624,010 20120413
- 主分类号： A61K39/155
- IPC分类号： A61K39/155 ; C07K14/135 ; C12N7/04
摘要：
Provided herein are recombinant respiratory syncytial viruses that contain mutations that make the disclosed viruses attractive vaccine candidates. The viruses disclosed contain attenuating mutations designed to have increased genetic and phenotypic stability. Desired combinations of these mutations can be made to achieve desired levels of attenation. Exemplary vaccine candidates are described. Also provided are polynucleotides capable of encoding the described viruses, as wells as methods for producing the viruses and methods of use.
摘要（中）：
本文提供了重组呼吸道合胞病毒，其包含使所公开的病毒具有吸引力的疫苗候选物的突变。 所公开的病毒包含设计为具有增加的遗传和表型稳定性的减毒突变。 可以进行这些突变的期望组合以达到期望的降低水平。 描述了示例性疫苗候选物。 还提供了能够编码所描述的病毒的多核苷酸，如作为生产病毒的方法以及使用方法的孔。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/12 | .病毒性抗原 |
| ----------A61K39/155 | ..副黏液病毒科，例如副流感病毒 |