基本信息:
- 专利标题： IMIDAZOLE DERIVATIVES
- 专利标题（中）：咪唑衍生物
- 申请号：PCT/US2012/064273 申请日：2012-11-09
- 公开(公告)号：WO2013074387A1 公开(公告)日：2013-05-23
- 发明人： LIU, Jian , BALKOVEC, James, M. , KRIKORIAN, Arto, D. , MILLER, Daniel, J. , GUIADEEN, Deodial , YANG, Ginger Xu-Qiang , JIAN, Tianying , WU, Zhicai , YU, Yang , NARGUND, Ravi, P. , VACHAL, Petr , HE, Shuwen , LAI, Zhong , HONG, Qingmei , DEVITA, Robert, J. , KIM, David , TING, Pauline, C.
- 申请人： MERCK SHARP & DOHME CORP. , LIU, Jian , BALKOVEC, James, M. , KRIKORIAN, Arto, D. , MILLER, Daniel, J. , GUIADEEN, Deodial , YANG, Ginger Xu-Qiang , JIAN, Tianying , WU, Zhicai , YU, Yang , NARGUND, Ravi, P. , VACHAL, Petr , HE, Shuwen , LAI, Zhong , HONG, Qingmei , DEVITA, Robert, J. , KIM, David , TING, Pauline, C.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,LIU, Jian,BALKOVEC, James, M.,KRIKORIAN, Arto, D.,MILLER, Daniel, J.,GUIADEEN, Deodial,YANG, Ginger Xu-Qiang,JIAN, Tianying,WU, Zhicai,YU, Yang,NARGUND, Ravi, P.,VACHAL, Petr,HE, Shuwen,LAI, Zhong,HONG, Qingmei,DEVITA, Robert, J.,KIM, David,TING, Pauline, C.
- 当前专利权人： MERCK SHARP & DOHME CORP.,LIU, Jian,BALKOVEC, James, M.,KRIKORIAN, Arto, D.,MILLER, Daniel, J.,GUIADEEN, Deodial,YANG, Ginger Xu-Qiang,JIAN, Tianying,WU, Zhicai,YU, Yang,NARGUND, Ravi, P.,VACHAL, Petr,HE, Shuwen,LAI, Zhong,HONG, Qingmei,DEVITA, Robert, J.,KIM, David,TING, Pauline, C.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： US61/559,303 20111114
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; C07D235/04 ; C07D235/18
摘要：
Disclosed herein are novel imidazole derivative compounds i.e., benzimidazole and aza-benzimidazole derivatives that act as DGAT1 inhibitors and can be useful in preventing, treating or acting as a remedial agent for hyperiipidemia, diabetes mellitus and obesity. Further disclosed are methods of treating various DGAT1 -related diseases, and the use of such imidazole compounds as described herein in the manufacture of a medicament for such treatment.
摘要（中）：
本文公开了新的咪唑衍生物化合物，即作为DGAT1抑制剂的苯并咪唑和氮杂 - 苯并咪唑衍生物，可用于预防，治疗或作为高脂血症，糖尿病和肥胖症的补救剂。 进一步公开的是治疗各种DGAT1相关疾病的方法，以及本文所述的这种咪唑化合物在制备用于这种治疗的药物中的用途。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/415 | ....1,2二唑 |
| ----------------A61K31/4184 | .....与碳环稠合的，例如苯并咪唑 |