基本信息:
- 专利标题： INHIBITION OF CLATHRIN
- 申请号：PCT/AU2012/000858 申请日：2012-07-16
- 公开(公告)号：WO2013010218A9 公开(公告)日：2013-01-24
- 发明人： HAUCKE, Volker , ROBINSON, Phillip , MCCLUSKEY, Adam
- 申请人： FREIE UNIVERSITÄT BERLIN , NEWCASTLE INNOVATION LIMITED , CHILDREN'S MEDICAL RESEARCH INSTITUTE , HAUCKE, Volker , ROBINSON, Phillip , MCCLUSKEY, Adam
- 申请人地址： Kaiserswerther Strasse 16-18 14195 Berlin DE
- 专利权人： FREIE UNIVERSITÄT BERLIN,NEWCASTLE INNOVATION LIMITED,CHILDREN'S MEDICAL RESEARCH INSTITUTE,HAUCKE, Volker,ROBINSON, Phillip,MCCLUSKEY, Adam
- 当前专利权人： FREIE UNIVERSITÄT BERLIN,NEWCASTLE INNOVATION LIMITED,CHILDREN'S MEDICAL RESEARCH INSTITUTE,HAUCKE, Volker,ROBINSON, Phillip,MCCLUSKEY, Adam
- 当前专利权人地址： Kaiserswerther Strasse 16-18 14195 Berlin DE
- 代理机构： ADAMS PLUCK
- 优先权： US61/508,600 20110715
- 主分类号： A61K31/00
- IPC分类号： A61K31/00 ; A61P31/00 ; A61P25/00 ; C40B30/02 ; C40B50/02 ; G06F19/18 ; G01N33/15 ; C07C13/547 ; C07C13/573 ; C07C13/66 ; C07D221/14 ; C07D221/16 ; C07D277/20 ; C07D277/36 ; C07D277/38 ; C07D277/34
摘要：
Inhibitors are provided for inhibiting the activity of clathrin. In particular, binding site(s) on the clathrin terminal doman (TD) for binding inhibitors have been identified. The binding sites are defined by amino acid(s) in the group Ile 52, Ile 62, Ile 80, Phe 91, and Ile 93 of the clathrin TD (SEQ ID No. 1). In at least some forms, the binding site may be further defined by amino acid(s) in the group Ile 66, Arg 64, Leu 82 andf Lys 96 of SEQ ID No. 1, or by Val 50 of SEQ ID No.1. There are also provided methods for prophylaxis or treatment of disease and conditions responsive to the inhibition of clathrin.
公开/授权文献:
- WO2013010218A1 INHIBITION OF CLATHRIN 公开/授权日：2013-01-24
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |