基本信息:
- 专利标题： CYCLOALKYL-FUSED TETRAHYDROQUINOLINES AS CRTH2 RECEPTOR MODULATORS
- 专利标题（中）：作为CRTH2受体调节剂的环丙基二烯丙基四氢喹啉
- 申请号：PCT/US2012/042336 申请日：2012-06-14
- 公开(公告)号：WO2012174176A1 公开(公告)日：2012-12-20
- 发明人： HUANG, Xianhai , BRUBAKER, Jason , PETERSON, Scott, L. , BUTCHER, John, W. , CLOSE, Joshua, T. , MARTINEZ, Michelle , MACCOSS, Rachel Nicola , JUNG, Joon, O. , SILIPHAIVANH, Phieng , ZHANG, Hongjun , ASLANIAN, Robert, G. , BIJU, Purakkattle Johny , DONG, Li , HUANG, Ying , MCCORMICK, Kevin, D. , PALANI, Anandan , SHAO, Ning , ZHOU, Wei
- 申请人： MERCK SHARP & DOHME CORP. , HUANG, Xianhai , BRUBAKER, Jason , PETERSON, Scott, L. , BUTCHER, John, W. , CLOSE, Joshua, T. , MARTINEZ, Michelle , MACCOSS, Rachel Nicola , JUNG, Joon, O. , SILIPHAIVANH, Phieng , ZHANG, Hongjun , ASLANIAN, Robert, G. , BIJU, Purakkattle Johny , DONG, Li , HUANG, Ying , MCCORMICK, Kevin, D. , PALANI, Anandan , SHAO, Ning , ZHOU, Wei
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK SHARP & DOHME CORP.,HUANG, Xianhai,BRUBAKER, Jason,PETERSON, Scott, L.,BUTCHER, John, W.,CLOSE, Joshua, T.,MARTINEZ, Michelle,MACCOSS, Rachel Nicola,JUNG, Joon, O.,SILIPHAIVANH, Phieng,ZHANG, Hongjun,ASLANIAN, Robert, G.,BIJU, Purakkattle Johny,DONG, Li,HUANG, Ying,MCCORMICK, Kevin, D.,PALANI, Anandan,SHAO, Ning,ZHOU, Wei
- 当前专利权人： MERCK SHARP & DOHME CORP.,HUANG, Xianhai,BRUBAKER, Jason,PETERSON, Scott, L.,BUTCHER, John, W.,CLOSE, Joshua, T.,MARTINEZ, Michelle,MACCOSS, Rachel Nicola,JUNG, Joon, O.,SILIPHAIVANH, Phieng,ZHANG, Hongjun,ASLANIAN, Robert, G.,BIJU, Purakkattle Johny,DONG, Li,HUANG, Ying,MCCORMICK, Kevin, D.,PALANI, Anandan,SHAO, Ning,ZHOU, Wei
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK SHARP & DOHME CORP.
- 优先权： US61/498,345 20110617
- 主分类号： A01N43/42
- IPC分类号： A01N43/42 ; C07D215/00
摘要：
The invention provides certain cycloalkyl-fused tetrahydroquinolines of the Formula (I), and their pharmaceutically acceptable salts and esters, wherein R 1 , R 2 , R 7 , R 8 , R 8a , E, Y, Z, n, u, and t are as defined herein. The invention also provides pharmaceutical compositions comprising such compounds, and methods of using the compounds for treating diseases or conditions associated with with uncontrolled or inappropriate stimulation of CRTH 2 function.
摘要（中）：
本发明提供一些式（I）的环烷基稠合的四氢喹啉及其药学上可接受的盐和酯，其中R1，R2，R7，R8，R8a，E，Y，Z，n，u和t如本文所定义 。 本发明还提供包含这些化合物的药物组合物，以及使用该化合物治疗与不受控制或不适当刺激CRTH2功能有关的疾病或病症的方法。