发明申请
WO2012135800A1 SUBSTITUTED N-PHENYLPYRIMIDIN-2-AMINE ANALOGS AS INHIBITORS OF THE AXL KINASE
审中-公开
基本信息:
- 专利标题： SUBSTITUTED N-PHENYLPYRIMIDIN-2-AMINE ANALOGS AS INHIBITORS OF THE AXL KINASE
- 专利标题（中）：取代的N-苯基嘧啶-2-胺类似物作为AXL激酶的抑制剂
- 申请号：PCT/US2012/031768 申请日：2012-03-31
- 公开(公告)号：WO2012135800A1 公开(公告)日：2012-10-04
- 发明人： BEARSS, David, J. , VANKAYALAPATI, Hariprasad , MOLLARD, Alexis , WARNER, Steven, L. , SHARMA, Sunil
- 申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , BEARSS, David, J. , VANKAYALAPATI, Hariprasad , MOLLARD, Alexis , WARNER, Steven, L. , SHARMA, Sunil
- 申请人地址： 615 Arapeen Drive, Suite 310 Salt Lake City, UT 84108 US
- 专利权人： UNIVERSITY OF UTAH RESEARCH FOUNDATION,BEARSS, David, J.,VANKAYALAPATI, Hariprasad,MOLLARD, Alexis,WARNER, Steven, L.,SHARMA, Sunil
- 当前专利权人： UNIVERSITY OF UTAH RESEARCH FOUNDATION,BEARSS, David, J.,VANKAYALAPATI, Hariprasad,MOLLARD, Alexis,WARNER, Steven, L.,SHARMA, Sunil
- 当前专利权人地址： 615 Arapeen Drive, Suite 310 Salt Lake City, UT 84108 US
- 代理机构： SHORTELL, Brian, D. et al.
- 优先权： US61/471,090 20110401
- 主分类号： A01N43/54
- IPC分类号： A01N43/54 ; C07D239/02
摘要：
In one aspect, the invention relates to substituted N-phenylpyrimidin-2-amine analogs, derivatives thereof, and related compounds, which are useful as inhibitors of Axl kinase; synthetic methods for making the compounds; pharmaceutical compositions comprising the compounds; and methods of using the compounds and compositions for treating disorders associated with dysfunction of the Axl kinase. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要（中）：
一方面，本发明涉及可用作Ax1激酶抑制剂的取代的N-苯基嘧啶-2-胺类似物，其衍生物和相关化合物。 制备化合物的合成方法; 包含该化合物的药物组合物; 以及使用化合物和组合物治疗与Axl激酶功能障碍相关的疾病的方法。 该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。