基本信息:
- 专利标题: BISPECIFIC BINDING MOLECULES BINDING TO VEGF AND ANG2
- 专利标题(中):双向结合分子与VEGF和ANG2结合
- 申请号:PCT/EP2012/055901 申请日:2012-03-30
- 公开(公告)号:WO2012131078A1 公开(公告)日:2012-10-04
- 发明人: GSCHWIND, Andreas , OTT, Rene Georg , BOUCNEAU, Joachim , BUYSE, Marie-Ange , DEPLA, Erik
- 申请人: BOEHRINGER INGELHEIM INTERNATIONAL GMBH , GSCHWIND, Andreas , OTT, Rene Georg , BOUCNEAU, Joachim , BUYSE, Marie-Ange , DEPLA, Erik
- 申请人地址: Binger Strasse 173 55216 Ingelheim am Rhein DE
- 专利权人: BOEHRINGER INGELHEIM INTERNATIONAL GMBH,GSCHWIND, Andreas,OTT, Rene Georg,BOUCNEAU, Joachim,BUYSE, Marie-Ange,DEPLA, Erik
- 当前专利权人: BOEHRINGER INGELHEIM INTERNATIONAL GMBH,GSCHWIND, Andreas,OTT, Rene Georg,BOUCNEAU, Joachim,BUYSE, Marie-Ange,DEPLA, Erik
- 当前专利权人地址: Binger Strasse 173 55216 Ingelheim am Rhein DE
- 代理机构: HAMMANN, Heinz et al.
- 优先权: EP11160921.0 20110401
- 主分类号: C07K16/22
- IPC分类号: C07K16/22 ; C07K16/26
摘要:
Bispecifc binding molecules binding to both VEGF and Ang2, preferably in the form of immunoglobulin single variable domains like VHHs and domain antibodies, pharmaceutical compositions containing the same and their use in the treatment of diseases that are associated with VEGF- and/or Ang2- mediated effects on angiogenesis are disclosed. Further, nucleic acids encoding bispecific binding molecules, host cells and methods for preparing same are also described.
摘要(中):
结合VEGF和Ang2的双歧杆菌结合分子,优选以免疫球蛋白单可变结构域(如VHH和结构域抗体)的形式,含有它们的药物组合物及其在治疗与VEGF-和/或Ang2-介导的相关疾病中的用途 公开了对血管发生的作用。 此外,还描述了编码双特异性结合分子的核酸,宿主细胞及其制备方法。