发明申请
WO2012113067A1 OLIGONUCLEOTIDE INHIBITORS WITH CHIMERIC BACKBONE AND 2-AMINO-2'-DEOXYADENOSINE
审中-公开
基本信息:
- 专利标题： OLIGONUCLEOTIDE INHIBITORS WITH CHIMERIC BACKBONE AND 2-AMINO-2'-DEOXYADENOSINE
- 专利标题（中）：寡核苷酸抑制剂和二氨基-2'-脱氧腺苷
- 申请号：PCT/CA2012/000169 申请日：2012-02-23
- 公开(公告)号：WO2012113067A1 公开(公告)日：2012-08-30
- 发明人： SEGUIN, Rosanne , FERRARI, Nicolay
- 申请人： PHARMAXIS LTD , SEGUIN, Rosanne , FERRARI, Nicolay
- 申请人地址： 20 Rodborough Road Frenchs Forest, New South Wales 2086 AU
- 专利权人： PHARMAXIS LTD,SEGUIN, Rosanne,FERRARI, Nicolay
- 当前专利权人： PHARMAXIS LTD,SEGUIN, Rosanne,FERRARI, Nicolay
- 当前专利权人地址： 20 Rodborough Road Frenchs Forest, New South Wales 2086 AU
- 代理机构： NORTON ROSE CANADA LLP/S.E.N.C.R.L., s.r.l. et al.
- 优先权： US61/446,144 20110224
- 主分类号： C12N15/113
- IPC分类号： C12N15/113 ; A61K31/7125 ; A61P11/00 ; A61P29/00 ; C07H21/00 ; C12N15/19 ; C12N15/55
摘要：
There is provided herein, an oligonucleotide directed against a target gene, wherein the oligonucleotide is capable of hybridizing to at least a portion of a nucleic acid sequence encoding the gene under stringent conditions, and wherein, at least one nucleotide of the oligonucleotide is 2-amino-2'- deoxyadenosine (DAP); and the internucleoside linkages of the oligonucleotide comprises at least three alternating segments, each segment consisting of either at least one phosphorothioate or at least one phosphodiester bond.
摘要（中）：
本文提供了针对靶基因的寡核苷酸，其中所述寡核苷酸能够在严格条件下与至少一部分编码该基因的核酸序列杂交，并且其中寡核苷酸的至少一个核苷酸为2- 氨基-2'-脱氧腺苷（DAP）; 并且寡核苷酸的核苷间键包含至少三个交替区段，每个区段由至少一个硫代磷酸酯或至少一个磷酸二酯键组成。