发明申请
WO2012103450A3 METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
审中-公开
基本信息:
- 专利标题： METHODS AND COMPOSITIONS FOR DIAGNOSIS AND PROGNOSIS OF RENAL INJURY AND RENAL FAILURE
- 专利标题（中）：用于诊断和预防肾损伤和肾功能衰竭的方法和组合
- 申请号：PCT/US2012022926 申请日：2012-01-27
- 公开(公告)号：WO2012103450A3 公开(公告)日：2014-04-10
- 发明人： ANDERBERG JOSEPH , GRAY JEFF , MCPHERSON PAUL , NAKAMURA KEVIN , KAMPF JAMES PATRICK
- 申请人： ASTUTE MEDICAL INC , ANDERBERG JOSEPH , GRAY JEFF , MCPHERSON PAUL , NAKAMURA KEVIN , KAMPF JAMES PATRICK
- 专利权人： ASTUTE MEDICAL INC,ANDERBERG JOSEPH,GRAY JEFF,MCPHERSON PAUL,NAKAMURA KEVIN,KAMPF JAMES PATRICK
- 当前专利权人： ASTUTE MEDICAL INC,ANDERBERG JOSEPH,GRAY JEFF,MCPHERSON PAUL,NAKAMURA KEVIN,KAMPF JAMES PATRICK
- 优先权： US201161437618 2011-01-29; US201161437613 2011-01-29; US201161437621 2011-01-29
- 主分类号： G01N33/48
- IPC分类号： G01N33/48
摘要：
The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using a one or more assays configured to detect a kidney injury marker selected from the group consisting of Angiopoietin-related protein 3, Soluble Lymphatic vessel endothelial hyaluronic acid receptor 1, and Vascular endothelial growth factor D as diagnostic and prognostic biomarkers in renal injuries.
摘要（中）：
本发明涉及用于在患有或疑似患有肾损伤的受试者中监测，诊断，预后和确定治疗方案的方法和组合物。 特别地，本发明涉及使用一种或多种测定法，其被配置为检测选自以下的肾损伤标志物：血管生成素相关蛋白3，可溶性淋巴管内皮透明质酸受体1和血管内皮生长因子D作为诊断和 肾损伤的预后生物标志物。