Provided is a shoe for a patient in a leg cast, which is comfortable to wear, which enables the angle of a band to be adjusted, and which provides high durability. The shoe comprises: a sole having an upper surface and a lower surface having respective anti-slip protrusions; first support members protruded from respective left and right sides of the sole; a second support member protruding to cover a rear portion of the sole; first shape corresponding means for separably interconnecting left and right first support members and covering the leg cast according to the shape of a front portion of the leg cast of the patient; and second shape corresponding means for separably interconnecting front portions of the second support member and covering the leg cast according to the shape of a rear portion of the leg cast of the patient. Each of the first and second shape corresponding means comprises: a strip-shaped band; a Velcro fastener provided at any one of both ends of the band so as to separably interconnect the first support members or the second support member; and varying coupling means provided at the other end of the band to vary the position of the band in accordance with the shape of the leg cast.