发明申请
WO2012061100A2 SCREENING METHODS OF MODULATING ADRENERGIC RECEPTOR GENE EXPRESSIONS IMPLICATED IN MELANOGENESIS
审中-公开
基本信息:
- 专利标题： SCREENING METHODS OF MODULATING ADRENERGIC RECEPTOR GENE EXPRESSIONS IMPLICATED IN MELANOGENESIS
- 专利标题（中）：调控嗜酸性粒细胞趋化因子基因表达的筛选方法
- 申请号：PCT/US2011/057608 申请日：2011-10-25
- 公开(公告)号：WO2012061100A2 公开(公告)日：2012-05-10
- 发明人： LAUGHLIN, Leo, Timothy, II , HAKOZAKI, Tomohiro , ZHAO, Wenzhu , WANG, Jiazhen , BIERMAN, John, Crist
- 申请人： THE PROCTER & GAMBLE COMPANY , LAUGHLIN, Leo, Timothy, II , HAKOZAKI, Tomohiro , ZHAO, Wenzhu , WANG, Jiazhen , BIERMAN, John, Crist
- 申请人地址： One Procter & Gamble Plaza Cincinnati, Ohio 45202 US
- 专利权人： THE PROCTER & GAMBLE COMPANY,LAUGHLIN, Leo, Timothy, II,HAKOZAKI, Tomohiro,ZHAO, Wenzhu,WANG, Jiazhen,BIERMAN, John, Crist
- 当前专利权人： THE PROCTER & GAMBLE COMPANY,LAUGHLIN, Leo, Timothy, II,HAKOZAKI, Tomohiro,ZHAO, Wenzhu,WANG, Jiazhen,BIERMAN, John, Crist
- 当前专利权人地址： One Procter & Gamble Plaza Cincinnati, Ohio 45202 US
- 代理机构： THE PROCTER & GAMBLE COMPANY
- 优先权： US61/406,338 20101025
- 主分类号： G01N33/50
- IPC分类号： G01N33/50 ; G01N33/94
摘要：
Embodiments of screening methods for determining test agents effective for modifying the appearance of pigmented skin are provided. The screening method may comprise the steps of contacting a cell, a cell culture, or bulk cells with the test agent, wherein the cell, the cell culture, or the bulk cells comprise ADR?1 receptors, and determining based on the binding interaction of the test agent with the ADR?1 receptors whether the test agent is an effective ADR?1 receptor antagonist suitable for modifying the appearance of pigmented skin, wherein a test agent is considered to be an effective ADR?1 receptor antagonist when it defines a half maximal inhibitory concentration of less than about 1000 ppm.
摘要（中）：
提供了用于确定有效改善着色皮肤外观的试验剂的筛选方法的实施方案。 筛选方法可以包括使细胞，细胞培养物或体细胞与测试试剂接触的步骤，其中细胞，细胞培养物或大体细胞包含ADRα1受体，并且基于 具有ADR1受体的测试剂是否适合于修饰着色皮肤外观的有效的ADRα1受体拮抗剂，其中当定义半衰期时，被认为是有效的ADRα1受体拮抗剂 最大抑制浓度小于约1000ppm。