On a machine tool which has a tool spindle (26) for mounting a machining tool (1-7) and a tool magazine (50) with a multiplicity of magazine locations (a - z), which are loaded with a multiplicity of machining tools (1 - 10) in a spatial sequence in relation to one another, the machining tools (1 - 10) are rearranged in conjunction with the machining of a specific workpiece in such a way that the spatial sequence (a - z) corresponds at least largely to the time sequence (1 - 10). In this case, the following steps are carried out: a) the tool spindle (26) deposits the previously used machining tool (1) in the first magazine location (a), b) the tool spindle (26) removes the machining tool (5) from the second magazine location (b) and deposits it in a machine location (d) serving as an interim store, c) the tool spindle (26) removes the machining tool (2) intended in the time sequence to be the next for machining from its old magazine location (y) and carries out a machining of the workpiece (42) with it, d) the tool spindle (26) deposits the machining tool (2) in the machine location (b), and e) the tool spindle (26) removes the machining tool (6) from the third machine location (c).