基本信息:
- 专利标题： ANTHRAQUINONE COMPOUNDS AND THEIR USES
- 专利标题（中）：蒽醌化合物及其用途
- 申请号：PCT/EP2011/066053 申请日：2011-09-15
- 公开(公告)号：WO2012035122A1 公开(公告)日：2012-03-22
- 发明人： THORNBURY, Keith , SERGEANT, Gerard Patrick , MCHALE, Noel , ROY, Subhrangsu , HOLLYWOOD, Mark Anthony
- 申请人： DUNDALK INSTITUTE OF TECHNOLOGY , THORNBURY, Keith , SERGEANT, Gerard Patrick , MCHALE, Noel , ROY, Subhrangsu , HOLLYWOOD, Mark Anthony
- 申请人地址： Dublin Road Dundalk, County Louth IE
- 专利权人： DUNDALK INSTITUTE OF TECHNOLOGY,THORNBURY, Keith,SERGEANT, Gerard Patrick,MCHALE, Noel,ROY, Subhrangsu,HOLLYWOOD, Mark Anthony
- 当前专利权人： DUNDALK INSTITUTE OF TECHNOLOGY,THORNBURY, Keith,SERGEANT, Gerard Patrick,MCHALE, Noel,ROY, Subhrangsu,HOLLYWOOD, Mark Anthony
- 当前专利权人地址： Dublin Road Dundalk, County Louth IE
- 代理机构： O'CONNELL, Maura
- 优先权： GB1114855.8 20110829; EP10009835.9 20100917
- 主分类号： C07D257/04
- IPC分类号： C07D257/04 ; C07C309/53 ; A61K31/185 ; A61K31/192 ; A61K31/277 ; A61P1/04 ; A61P1/10 ; A61P9/00 ; A61P9/10 ; A61P11/06 ; A61P13/00
摘要：
The present invention relates to a compound comprising a substituted or unsubstituted anthraquinone, or a salt or isomer thereof, for use in treating a disorder caused by or associated with dysfunctional ion channel activity. The invention finds utility in the treatment of disorders associated with smooth muscle tone and contraction, such as arterial hypertension; myocardial infarction; faecal incontinence; constipation; gastro oesophageal reflux; impaired gastrointestinal passage; urinary incontinence; erectile dysfunction; and asthma.
摘要（中）：
本发明涉及包含取代或未取代的蒽醌或其盐或异构体的化合物，其用于治疗由功能障碍性离子通道活性引起或与功能障碍的离子通道活性相关的病症。 本发明可用于治疗与平滑肌张力和收缩相关的疾病，例如动脉高血压; 心肌梗死; 大便失禁 便秘; 胃食管反流; 胃肠通道受损; 尿失禁 勃起功能障碍 和哮喘。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D257/00 | 杂环化合物，有4个氮原子作为仅有的杂环原子的环 |
| --------C07D257/02 | .不与其他环稠合 |
| ----------C07D257/04 | ..五元环 |