基本信息:
- 专利标题： COMPOUNDS AND METHODS FOR INHIBITING PHOSPHATE TRANSPORT
- 专利标题（中）：抑制磷酸盐运输的化合物和方法
- 申请号：PCT/US2011/043266 申请日：2011-07-07
- 公开(公告)号：WO2012006477A1 公开(公告)日：2012-01-12
- 发明人： LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric
- 申请人： ARDELYX, INC. , LEWIS, Jason, G. , JACOBS, Jeffrey, W. , REICH, Nicholas , LEADBETTER, Michael, R. , BELL, Noah , CHANG, Han-Ting , CHEN, Tao , NAVRE, Marc , CHARMOT, Dominique , CARRERAS, Christopher , LABONTE, Eric
- 申请人地址： 34175 Ardenwood Blvd. Fremont, California 94555 US
- 专利权人： ARDELYX, INC.,LEWIS, Jason, G.,JACOBS, Jeffrey, W.,REICH, Nicholas,LEADBETTER, Michael, R.,BELL, Noah,CHANG, Han-Ting,CHEN, Tao,NAVRE, Marc,CHARMOT, Dominique,CARRERAS, Christopher,LABONTE, Eric
- 当前专利权人： ARDELYX, INC.,LEWIS, Jason, G.,JACOBS, Jeffrey, W.,REICH, Nicholas,LEADBETTER, Michael, R.,BELL, Noah,CHANG, Han-Ting,CHEN, Tao,NAVRE, Marc,CHARMOT, Dominique,CARRERAS, Christopher,LABONTE, Eric
- 当前专利权人地址： 34175 Ardenwood Blvd. Fremont, California 94555 US
- 代理机构： HERMANNS, Karl, R. et al.
- 优先权： US61/362,133 20100707
- 主分类号： A01N43/38
- IPC分类号： A01N43/38 ; A61K31/405
摘要：
Compounds having activity as phosphate transport inhibitors, more specifically, inhibitors of intestinal apical membrane Na/phosphate co-transport, are disclosed. The compounds have the following structure (I): including stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, wherein X, Y, R 1 and R 2 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.
摘要（中）：
具有作为磷酸盐转运抑制剂的活性的化合物，更具体地，公开了肠顶膜Na /磷酸盐共转运的抑制剂。 所述化合物具有以下结构（I）：包括立体异构体，其药学上可接受的盐和前药，其中X，Y，R 1和R 2如本文所定义。 还公开了与这种化合物的制备和使用相关的方法以及包含这些化合物的药物组合物。