发明申请
WO2011156841A1 LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, THERMAL LYSIS, NUCLEIC ACID AMPLIFICATION AND PREHYBRIDIZATION FILTERING
审中-公开
基本信息:
- 专利标题： LOC DEVICE FOR PATHOGEN DETECTION WITH DIALYSIS, THERMAL LYSIS, NUCLEIC ACID AMPLIFICATION AND PREHYBRIDIZATION FILTERING
- 专利标题（中）：用于通过透析，热分析，核酸扩增和预结晶过滤进行病原体检测的LOC装置
- 申请号：PCT/AU2011/000664 申请日：2011-06-01
- 公开(公告)号：WO2011156841A1 公开(公告)日：2011-12-22
- 发明人： SILVERBROOK, Kia , AZIMI, Mehdi , FACER, Geoffrey Richard , MOINI, Alireza
- 申请人： GENEASYS PTY LTD , SILVERBROOK, Kia , AZIMI, Mehdi , FACER, Geoffrey Richard , MOINI, Alireza
- 申请人地址： 558 Darling Street Rozelle, New South Wales 2039 AU
- 专利权人： GENEASYS PTY LTD,SILVERBROOK, Kia,AZIMI, Mehdi,FACER, Geoffrey Richard,MOINI, Alireza
- 当前专利权人： GENEASYS PTY LTD,SILVERBROOK, Kia,AZIMI, Mehdi,FACER, Geoffrey Richard,MOINI, Alireza
- 当前专利权人地址： 558 Darling Street Rozelle, New South Wales 2039 AU
- 代理机构： GENEASYS PTY LTD
- 优先权： US61/437,686 20110130; US61/356,018 20100617
- 主分类号： B81B7/02
- IPC分类号： B81B7/02 ; C12Q1/00 ; G01N33/50
摘要：
A lab-on-a-chip (LOC) device for pathogen detection, genetic analysis and proteomic analysis of a biological sample, using a leukocyte dialysis section for dividing the sample into a leukocyte stream, and a pathogen and erythrocyte, a pathogen dialysis section for dividing the pathogen and erythrocyte stream into an erythrocyte stream and a pathogen stream, a leukocyte lysis section downstream of the leukocyte dialysis section, a leukocyte incubation section downstream of the leukocyte lysis section, a pathogen lysis section downstream of the pathogen dialysis section, a pathogen incubation section downstream of the pathogen lysis section, an erythrocyte lysis section downstream of the pathogen dialysis section, a first leukocyte nucleic acid amplification section downstream of the leukocyte incubation section, a second leukocyte nucleic acid amplification section downstream of the first leukocyte nucleic acid amplification section, a first pathogen nucleic acid amplification section downstream of the pathogen incubation section, and, a second pathogen nucleic acid amplification section downstream of the first pathogen nucleic acid amplification.
摘要（中）：
用于病原体检测，遗传分析和生物样品的蛋白质组学分析的实验室（LOC）装置，使用白细胞透析部分将样品分成白细胞流，以及病原体和红细胞，病原体透析部分 用于将病原体和红细胞流分成红细胞流和病原体流，白细胞透析部分下游的白细胞裂解部分，白细胞裂解部分下游的白细胞孵育部分，病原体透析部分下游的病原体裂解部分， 病原体裂解部分下游的病原体孵育部分，病原体透析部分下游的红细胞裂解部分，白细胞孵育部分下游的第一白细胞核酸扩增部分，第一白细胞核酸扩增下游的第二白细胞核酸扩增部分 第一个病原体核酸扩增部分d 病原体孵育部分的自身流，以及第一病原体核酸扩增下游的第二病原体核酸扩增部分。
IPC结构图谱:
| B | 作业；运输 |
| --B81 | 微观结构技术 |
| ----B81B | 微观结构的装置或系统，例如微观机械装置 |
| ------B81B7/00 | 微观结构系统 |
| --------B81B7/02 | .包括功能上有特定关系的不同的电或光学装置，例如微—电子—机械系统（MEMS） |