发明申请
WO2011153458A2 COMPOSITIONS AND METHODS FOR INHIBITION OF OR TREATMENT OF DENGUE VIRUS INFECTION
审中-公开
基本信息:
- 专利标题： COMPOSITIONS AND METHODS FOR INHIBITION OF OR TREATMENT OF DENGUE VIRUS INFECTION
- 专利标题（中）：用于抑制或治疗登革热病毒感染的组合物和方法
- 申请号：PCT/US2011/039107 申请日：2011-06-03
- 公开(公告)号：WO2011153458A2 公开(公告)日：2011-12-08
- 发明人： AREVALO, Maria T. , SIMPSON-HAIDARIS, Patricia J. , JIN, Xia , CHEN, Huiyuan , QUINN, Matthew H.
- 申请人： UNIVERSITY OF ROCHESTER , AREVALO, Maria T. , SIMPSON-HAIDARIS, Patricia J. , JIN, Xia , CHEN, Huiyuan , QUINN, Matthew H.
- 申请人地址： 601 Elmwood Avenue, Box OTT Rochester, NY 14642 US
- 专利权人： UNIVERSITY OF ROCHESTER,AREVALO, Maria T.,SIMPSON-HAIDARIS, Patricia J.,JIN, Xia,CHEN, Huiyuan,QUINN, Matthew H.
- 当前专利权人： UNIVERSITY OF ROCHESTER,AREVALO, Maria T.,SIMPSON-HAIDARIS, Patricia J.,JIN, Xia,CHEN, Huiyuan,QUINN, Matthew H.
- 当前专利权人地址： 601 Elmwood Avenue, Box OTT Rochester, NY 14642 US
- 代理机构： MERKEL, Edwin, V. et al.
- 优先权： US61/351,071 20100603
摘要：
The present invention relates to a method of interfering with dengue infection comprising interfering with dengue virus binding to a syndecan present on a cell targeted by dengue virus. The present invention further relates to treating a patient for dengue virus infection comprising administering to a patient, either having a dengue infection or a patient exposed to dengue infection, an effective amount of an agent that interferes with dengue virus binding to a syndecan on a surface of a cell targeted by dengue virus. The present invention further relates to a pharmaceutical composition comprising a pharmaceutically acceptable carrier, and an effective amount of an agent that interferes with dengue virus binding to a syndecan on a surface of a cell targeted by dengue virus.
摘要（中）：
本发明涉及一种干扰登革热感染的方法，包括干扰登革热病毒与存在于登革热病毒靶向的细胞上的syndecan结合。 本发明还涉及治疗患者登革热病毒感染的方法，其包括对具有登革热感染或暴露于登革热感染的患者施用有效量的与登革热病毒结合在表面上的突变体的登革热病毒 由登革热病毒靶向的细胞。 本发明还涉及包含药学上可接受的载体的药物组合物和有效量的与登革热病毒结合登革热病毒靶向的细胞表面上的突变型病毒的药剂。