发明申请
WO2011151624A8 METHOD FOR MONOFLUOROMETHYLATION OF ORGANIC SUBSTRATES TO PREPARE BIOLOGICALLY ACTIVE ORGANIC COMPOUNDS
审中-公开
基本信息:
- 专利标题： METHOD FOR MONOFLUOROMETHYLATION OF ORGANIC SUBSTRATES TO PREPARE BIOLOGICALLY ACTIVE ORGANIC COMPOUNDS
- 申请号：PCT/GB2011000834 申请日：2011-06-01
- 公开(公告)号：WO2011151624A8 公开(公告)日：2013-01-03
- 发明人： LEITAO EMILIA PERPETUA TAVARES
- 申请人： HOVIONE INT LTD , LEITAO EMILIA PERPETUA TAVARES , TURNER CRAIG ROBERT
- 专利权人： HOVIONE INT LTD,LEITAO EMILIA PERPETUA TAVARES,TURNER CRAIG ROBERT
- 当前专利权人： HOVIONE INT LTD,LEITAO EMILIA PERPETUA TAVARES,TURNER CRAIG ROBERT
- 优先权： PT10513910 2010-06-01
- 主分类号： C07J31/00
- IPC分类号： C07J31/00
摘要：
The present invention describes a process for the preparation of monofluoromethylated organic biologically active compounds using monofluoromethylated reagents. Fluticasone Propionate and Fluticasone Furoate can be prepared using, for example, S-monofluoromethyl-S-phenyl-2,3,4,5- tetramethylphenylsulfonium tetrafluoroborate as monofluoromethylating reagent instead of bromofluoromethane.