发明申请
WO2011149874A2 N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1
审中-公开
基本信息:
- 专利标题： N-PHENYL IMIDAZOLE CARBOXAMIDE INHIBITORS OF 3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE-1
- 专利标题（中）：3-磷酸腺苷依赖性蛋白激酶-1的N-苯基咪唑酰胺酰胺抑制剂
- 申请号：PCT/US2011/037651 申请日：2011-05-24
- 公开(公告)号：WO2011149874A2 公开(公告)日：2011-12-01
- 发明人： TSUI, Hon-Chung , PALIWAL, Sunil , KIM, Hyunjin, M. , KEREKES, Angela, D. , CAPLEN, Mary Ann , ESPOSITE, Sara, J. , MCKITTRICK, Brian, A. , FISCHMANN, Thierry Olivier , DOLL, Ronald, J. , RAINKA, Matthew Paul , LI, Ang
- 申请人： SCHERING CORPORATION , TSUI, Hon-Chung , PALIWAL, Sunil , KIM, Hyunjin, M. , KEREKES, Angela, D. , CAPLEN, Mary Ann , ESPOSITE, Sara, J. , MCKITTRICK, Brian, A. , FISCHMANN, Thierry Olivier , DOLL, Ronald, J. , RAINKA, Matthew Paul , LI, Ang
- 申请人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033 US
- 专利权人： SCHERING CORPORATION,TSUI, Hon-Chung,PALIWAL, Sunil,KIM, Hyunjin, M.,KEREKES, Angela, D.,CAPLEN, Mary Ann,ESPOSITE, Sara, J.,MCKITTRICK, Brian, A.,FISCHMANN, Thierry Olivier,DOLL, Ronald, J.,RAINKA, Matthew Paul,LI, Ang
- 当前专利权人： SCHERING CORPORATION,TSUI, Hon-Chung,PALIWAL, Sunil,KIM, Hyunjin, M.,KEREKES, Angela, D.,CAPLEN, Mary Ann,ESPOSITE, Sara, J.,MCKITTRICK, Brian, A.,FISCHMANN, Thierry Olivier,DOLL, Ronald, J.,RAINKA, Matthew Paul,LI, Ang
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033 US
- 代理机构： LEFF, Matthew, A.
- 优先权： US61/348,538 20100526
- 主分类号： C07D403/02
- IPC分类号： C07D403/02
摘要：
The present invention provides Imidazole Carboxamide Compounds of Formula (I): wherein D, T, R 1 , R 2 , R 3 , and R 6 are as defined herein, and pharmaceutically acceptable salts of such Imidazole Carboxamide Compounds. The Imidazole Carboxamide Compounds are useful in the treatment of cancer and other aberrant conditions that result from overstimulation of the PDK-1 signaling pathway.
摘要（中）：
本发明提供式（I）的咪唑羧酰胺化合物：其中D，T，R 1，R 2，R 3和R 6如本文所定义，以及这些咪唑羧酰胺化合物的药学上可接受的盐。 咪唑羧酰胺化合物可用于治疗由过度刺激PDK-1信号通路引起的癌症和其他异常病症。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D403/00 | 杂环化合物，含有两个或更多的杂环，以氮原子作为仅有的杂环原子，C07D401/00组不包含的 |
| --------C07D403/02 | .含两个杂环 |