发明申请
WO2011146269A1 TECHNIQUES FOR AUTOMATED PARAMETER ADJUSTMENT USING ION SIGNAL INTENSITY FEEDBACK
审中-公开
基本信息:
- 专利标题: TECHNIQUES FOR AUTOMATED PARAMETER ADJUSTMENT USING ION SIGNAL INTENSITY FEEDBACK
- 专利标题(中):使用离子信号强度反馈进行自动参数调整的技术
- 申请号:PCT/US2011/035693 申请日:2011-05-09
- 公开(公告)号:WO2011146269A1 公开(公告)日:2011-11-24
- 发明人: TOMANY, Michael, J. , MURPHY, James, P. , RAINVILLE, Paul
- 申请人: WATERS TECHNOLOGIES CORPORATION , TOMANY, Michael, J. , MURPHY, James, P. , RAINVILLE, Paul
- 申请人地址: 34 Maple Street Milford, MA 01757 US
- 专利权人: WATERS TECHNOLOGIES CORPORATION,TOMANY, Michael, J.,MURPHY, James, P.,RAINVILLE, Paul
- 当前专利权人: WATERS TECHNOLOGIES CORPORATION,TOMANY, Michael, J.,MURPHY, James, P.,RAINVILLE, Paul
- 当前专利权人地址: 34 Maple Street Milford, MA 01757 US
- 代理机构: ROSE, Jamie, H. et al.
- 优先权: US61/347,029 20100521
- 主分类号: H01J49/00
- IPC分类号: H01J49/00 ; B01D59/44 ; G01N30/00
摘要:
Described are techniques for tuning parameters of a system. For one or more values of a distance, mass spectral analysis of a liquid analyte stream is performed. A corresponding ion signal intensity of a selected ion is obtained. The distance is measured from a first end of a first tube to a second end of a second tube which surrounds said first tube. Using a computing device, a current value of the distance is automatically adjusted in accordance with corresponding ion signal intensities obtained for the selected ion. Using a computing device, a desired value for the distance is automatically determined using the corresponding ion signal intensities. The desired value results in an ion signal intensity for the selected ion which is any of more than a threshold intensity and a maximum of ion signal intensities obtained by performing mass spectral analysis using different values for the distance.
摘要(中):
描述了用于调整系统参数的技术。 对于一个或多个距离的值,进行液体分析物流的质谱分析。 获得所选离子的对应离子信号强度。 距离是从第一管的第一端到围绕所述第一管的第二管的第二端测量的。 使用计算设备,根据为所选择的离子获得的对应的离子信号强度,自动调整距离的当前值。 使用计算设备,使用相应的离子信号强度自动确定距离的期望值。 期望的值导致所选择的离子的离子信号强度,其通过使用不同的距离值进行质谱分析而获得的超过阈值强度和离子信号强度的最大值中的任何一个。