基本信息:
- 专利标题: FLUORESCENT FUSION POLYPEPTIDES AND METHODS OF USE
- 专利标题(中):荧光熔融聚合物及其使用方法
- 申请号:PCT/US2011/034330 申请日:2011-04-28
- 公开(公告)号:WO2011137243A2 公开(公告)日:2011-11-03
- 发明人: MARKIV, Anatoliy , DURVASULA, Ravi , KANG, Angray, Singh
- 申请人: STC.UNM , MARKIV, Anatoliy , DURVASULA, Ravi , KANG, Angray, Singh
- 申请人地址: 801 University Boulevard, S.E. Suite 101 Albuquerque, NM 87106 US
- 专利权人: STC.UNM,MARKIV, Anatoliy,DURVASULA, Ravi,KANG, Angray, Singh
- 当前专利权人: STC.UNM,MARKIV, Anatoliy,DURVASULA, Ravi,KANG, Angray, Singh
- 当前专利权人地址: 801 University Boulevard, S.E. Suite 101 Albuquerque, NM 87106 US
- 代理机构: GRAM, Christopher, D.
- 优先权: US61/343,627 20100430
- 主分类号: C07K19/00
- IPC分类号: C07K19/00 ; C12N15/62 ; G01N33/52
摘要:
Embodiments of the present invention provide for the facile generation of a stable recombinant fusion polypeptides with intrinsic fluorescent properties. The recombinant antibodies may be suitable for qualitative and/or quantitative immunofluorescence analysis. Generally, the fluorescent polypeptides include a fluorescent domain comprising a C-terminus and an N-terminus; a first antibody domain covalently linked to the C-terminus; and a second antibody domain covalently linked to the N-terminus.
摘要(中):
本发明的实施方案提供了容易地产生具有固有荧光性质的稳定的重组融合多肽。 重组抗体可适用于定性和/或定量免疫荧光分析。 通常,荧光多肽包括包含C末端和N末端的荧光结构域; 与C末端共价连接的第一抗体结构域; 和与N末端共价连接的第二抗体结构域。