发明申请
WO2011081904A1 DELIVERY OF TRANSTHYRETIN ACROSS THE BLOOD-BRAIN BARRIER AS A TREATMENT FOR ALZHEIMER'S DISEASE
审中-公开
基本信息:
- 专利标题： DELIVERY OF TRANSTHYRETIN ACROSS THE BLOOD-BRAIN BARRIER AS A TREATMENT FOR ALZHEIMER'S DISEASE
- 专利标题（中）：作为治疗阿尔茨海默病的血脑屏障的血液透析递送
- 申请号：PCT/US2010/060205 申请日：2010-12-14
- 公开(公告)号：WO2011081904A1 公开(公告)日：2011-07-07
- 发明人： MARUGAN, Juan Jose , ZHENG, Wei , MURO-GALINDO, Silvia
- 申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , UNIVERSITY OF MARYLAND, COLLEGE PARK , MARUGAN, Juan Jose , ZHENG, Wei , MURO-GALINDO, Silvia
- 申请人地址： Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 US
- 专利权人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,UNIVERSITY OF MARYLAND, COLLEGE PARK,MARUGAN, Juan Jose,ZHENG, Wei,MURO-GALINDO, Silvia
- 当前专利权人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES,UNIVERSITY OF MARYLAND, COLLEGE PARK,MARUGAN, Juan Jose,ZHENG, Wei,MURO-GALINDO, Silvia
- 当前专利权人地址： Office of Technology Transfer National Institutes of Health 6011 Executive Boulevard, Suite 325 MSC 7660 US
- 代理机构： JAY, Jeremy M. et al.
- 优先权： US61/286,205 20091214
- 主分类号： C07K14/47
- IPC分类号： C07K14/47 ; C07K14/705 ; C07K19/00 ; A61K38/17 ; A61K39/44 ; C12N1/16 ; C12N1/21 ; C12N5/10
摘要：
The invention provides a composition comprising transthyretin and an ICAM-1 targeting agent, wherein the transthyretin and ICAM-1 targeting agent are coupled together, as well as methods of preparing such compositions. The invention further provides a diabody capable of binding specifically to ICAM-1 and transthyretin. The invention also provides a method of use of such composition in the manufacture of a medicament for treating an amyloid-β related neurodegenerative disease, comprising administering to a subject a composition comprising transthyretin coupled to an ICAM-1 targeting agent in an amount effective to treat the neurodegenerative disease, wherein the composition is administered to the subject outside of the blood-brain barrier.
摘要（中）：
本发明提供了包含转甲状腺素蛋白和ICAM-1靶向剂的组合物，其中转甲状腺素蛋白和ICAM-1靶向剂偶联在一起，以及制备这种组合物的方法。 本发明还提供能够特异性结合ICAM-1和转甲状腺素蛋白的双抗体。 本发明还提供了这种组合物在制备用于治疗淀粉样蛋白ß相关神经变性疾病的药物中的应用的方法，包括向受试者施用包含与有效治疗的量的ICAM-1靶向剂偶联的转甲状腺素蛋白的组合物 所述神经变性疾病，其中所述组合物在所述血脑屏障外给予受试者。