发明申请
WO2011028488A1 UBIQUITIN PROTEASOME SYSTEM PROFILING AND THE USE THEREOF IN CLINICAL APPLICATIONS FOR PROLIFERATIVE HEMATOLOGICAL DISORDERS
审中-公开
基本信息:
- 专利标题： UBIQUITIN PROTEASOME SYSTEM PROFILING AND THE USE THEREOF IN CLINICAL APPLICATIONS FOR PROLIFERATIVE HEMATOLOGICAL DISORDERS
- 专利标题（中）：UBIQUITIN PROTEASOME系统分析及其在临床应用中对增生性血液病的用途
- 申请号：PCT/US2010/046369 申请日：2010-08-23
- 公开(公告)号：WO2011028488A1 公开(公告)日：2011-03-10
- 发明人： ALBITAR, Maher
- 申请人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED , ALBITAR, Maher , MA, Wanlong , ZHANG, Ke
- 申请人地址： 300 Delaware Avenue Wilmington, DE 19899 US
- 专利权人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED,ALBITAR, Maher,MA, Wanlong,ZHANG, Ke
- 当前专利权人： QUEST DIAGNOSTICS INVESTMENTS INCORPORATED,ALBITAR, Maher,MA, Wanlong,ZHANG, Ke
- 当前专利权人地址： 300 Delaware Avenue Wilmington, DE 19899 US
- 代理机构： KUHLMANN, Anthony C. et al.
- 优先权： US12/547,455 20090825
- 主分类号： C12Q1/37
- IPC分类号： C12Q1/37 ; G01N33/48
摘要：
Provided herein are methods for the diagnosis, prognosis, or management of proliferative hematological disorders and other diseases using profiles of the ubiquitin-proteasome system determined from acellular body fluids or cell-containing samples. Further provided are methods of predicting response to therapy in certain populations of leukemia patients.
摘要（中）：
本文提供了使用由无细胞体液或含细胞样品确定的泛素 - 蛋白酶体系统的概况来诊断，预后或管理增殖性血液病症和其它疾病的方法。 还提供了预测某些白血病患者群体治疗反应的方法。