发明申请
WO2010115252A1 PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF-a MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES
审中-公开
基本信息:
- 专利标题： PHTHALIMIDE DERIVATIVES OF NON-STEROIDAL ANTI-INFLAMMATORY COMPOUNDS AND/OR TNF-a MODULATORS, METHOD FOR PRODUCING SAME, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME AND USES THEREOF FOR THE TREATMENT OF INFLAMMATORY DISEASES
- 专利标题（中）：非甾体抗炎化合物和/或TNF-α调节剂的邻苯二甲酰衍生物，其制备方法，含有该组合物的药物组合物及其用于治疗炎症性疾病的用途
- 申请号：PCT/BR2010000099 申请日：2010-04-07
- 公开(公告)号：WO2010115252A1 公开(公告)日：2010-10-14
- 发明人： SANTOS JEAN LEANDRO DOS SANTOS , VIZIOLI EDNIR DE OLIVEIRA , CHIN CHUNG MAN , MENEGON RENATO FARINA , BLAU LORENA
- 申请人： EMS SA , UNIV ESTADUAL PAULISTA JULIO D , SANTOS JEAN LEANDRO DOS SANTOS , VIZIOLI EDNIR DE OLIVEIRA , CHIN CHUNG MAN , MENEGON RENATO FARINA , BLAU LORENA
- 专利权人： EMS SA,UNIV ESTADUAL PAULISTA JULIO D,SANTOS JEAN LEANDRO DOS SANTOS,VIZIOLI EDNIR DE OLIVEIRA,CHIN CHUNG MAN,MENEGON RENATO FARINA,BLAU LORENA
- 当前专利权人： EMS SA,UNIV ESTADUAL PAULISTA JULIO D,SANTOS JEAN LEANDRO DOS SANTOS,VIZIOLI EDNIR DE OLIVEIRA,CHIN CHUNG MAN,MENEGON RENATO FARINA,BLAU LORENA
- 优先权： BRPI0901298 2009-04-06
- 主分类号： C07D209/48
- IPC分类号： C07D209/48 ; A61K31/192 ; A61K31/196 ; A61K31/4035 ; A61K31/405 ; A61K31/60 ; A61K31/635 ; A61K31/655 ; A61P7/02 ; A61P29/00 ; C07C57/40 ; C07C65/10 ; C07C65/34 ; C07C209/28 ; C07C229/40 ; C07C229/42 ; C07C245/08 ; C07D209/28
摘要：
The present invention relates to phthalimide derivatives of non-steroidal anti-inflammatory compounds and/or TNF-a modulators, to a method for producing these derivatives, to pharmaceutical compositions containing these derivatives, and to uses thereof, including the use for the treatment of inflammatory diseases, in particular those associated with chronic inflammatory conditions, such as rheumatoid arthritis, and inflammatory intestinal diseases (such as Crohn's disease), and to the use of these compositions as antipyretics, analgesics and platelet aggregation inhibitors.
摘要（中）：
本发明涉及非甾体抗炎化合物和/或TNF-α调节剂的邻苯二甲酰亚胺衍生物，涉及制备这些衍生物的方法，含有这些衍生物的药物组合物及其应用，包括用于治疗 炎性疾病，特别是与慢性炎性病症如类风湿性关节炎和炎性肠病（如克罗恩病）相关的疾病，以及这些组合物用作解热药，镇痛药和血小板聚集抑制剂。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D209/00 | 杂环化合物，含五元环、与其他环稠合、带1个氮原子作为惟一的杂环原子 |
| --------C07D209/02 | .与一个碳环稠合 |
| ----------C07D209/04 | ..吲哚；氢化吲哚 |
| ------------C07D209/48 | ...在位置1和3有氧原子，例如邻苯二甲酰亚胺 |