基本信息:
- 专利标题： PROCESS FOR PURIFYING ESLICARBAZEPINE ACETATE
- 专利标题（中）：纯化乙酸钡乙酯的方法
- 申请号：PCT/IN2010000207 申请日：2010-03-30
- 公开(公告)号：WO2010113179A3 公开(公告)日：2011-01-27
- 发明人： KOILPILLAI JOSEPH PRABAHAR , KULKARNI PRAVIN BHALCHANDRA , SAWANT SACHIN BAPURAO , LIMBEKAR NAGESH DEVIDASRAO
- 申请人： GLENMARK GENERICS LTD , KOILPILLAI JOSEPH PRABAHAR , KULKARNI PRAVIN BHALCHANDRA , SAWANT SACHIN BAPURAO , LIMBEKAR NAGESH DEVIDASRAO
- 专利权人： GLENMARK GENERICS LTD,KOILPILLAI JOSEPH PRABAHAR,KULKARNI PRAVIN BHALCHANDRA,SAWANT SACHIN BAPURAO,LIMBEKAR NAGESH DEVIDASRAO
- 当前专利权人： GLENMARK GENERICS LTD,KOILPILLAI JOSEPH PRABAHAR,KULKARNI PRAVIN BHALCHANDRA,SAWANT SACHIN BAPURAO,LIMBEKAR NAGESH DEVIDASRAO
- 优先权： IN903MU2009 2009-04-02; IN1860MU2009 2009-08-12
- 主分类号： C07D223/28
- IPC分类号： C07D223/28 ; A61K31/55 ; A61P25/08 ; C07D223/24
摘要：
A process for purifying eslicarbazepine acetate is provided The crystalline particles of eslicarbazepine acetate having a median particle size between 5 µm and 20 µm and a specific surface area of from 0.1 m2/g to 10 m2/g as measured by B.E.T. method are obtained Eslicarbazepine acetate having purity greater than 99.0% as measured by high performance liquid chromatography and a pharmaceutical composition containing the same are also provided.
摘要（中）：
提供了一种纯化乙酸西酞西泮的方法。由B.E.T.测量的中等颗粒尺寸在5μm和20μm之间，比表面积为0.1m 2 / g至10m 2 / g的乙酸西酞西泮的结晶颗粒。 获得了通过高效液相色谱测定的纯度大于99.0％的乙酸西酞西泮乙酸盐和含有它们的药物组合物。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D223/00 | 杂环化合物，含七元环、有1个氮原子作为惟一的杂环原子 |
| --------C07D223/02 | .不与其他环稠合 |
| ----------C07D223/18 | ..二苯并吖庚因；氢化二苯并吖庚因 |
| ------------C07D223/22 | ...二苯并［b,f］吖庚因；氢化二苯并［b,f］吖庚因 |
| --------------C07D223/24 | ....有被氮原子取代的烃基，连在环氮原子上 |
| ----------------C07D223/28 | .....位置10与11间有1个单键 |