基本信息:
- 专利标题： METHODS AND MICROORGANISMS FOR PRODUCTION OF C4-DICARBOXYLIC ACIDS
- 专利标题（中）：用于生产C4-二羧酸的方法和微生物
- 申请号：PCT/US2010028429 申请日：2010-03-24
- 公开(公告)号：WO2010111344A3 公开(公告)日：2011-07-21
- 发明人： LAWRENCE ADAM , PRONK JACOBUS THOMAS , VAN MARIS ANTONIUS JEROEN ADRIAAN , ZELLE RINTZE MEINDERT , MADDEN KEVIN T , HARRISON JACOB C , TRUEHEART JOSHUA , GANCEDO RODRIGUEZ CARLOS , FLORES MAURIZ CARMEN-LISSET , BOWER STANLEY
- 申请人： MICROBIA INC , LAWRENCE ADAM , PRONK JACOBUS THOMAS , VAN MARIS ANTONIUS JEROEN ADRIAAN , ZELLE RINTZE MEINDERT , MADDEN KEVIN T , HARRISON JACOB C , TRUEHEART JOSHUA , GANCEDO RODRIGUEZ CARLOS , FLORES MAURIZ CARMEN-LISSET , BOWER STANLEY
- 专利权人： MICROBIA INC,LAWRENCE ADAM,PRONK JACOBUS THOMAS,VAN MARIS ANTONIUS JEROEN ADRIAAN,ZELLE RINTZE MEINDERT,MADDEN KEVIN T,HARRISON JACOB C,TRUEHEART JOSHUA,GANCEDO RODRIGUEZ CARLOS,FLORES MAURIZ CARMEN-LISSET,BOWER STANLEY
- 当前专利权人： MICROBIA INC,LAWRENCE ADAM,PRONK JACOBUS THOMAS,VAN MARIS ANTONIUS JEROEN ADRIAAN,ZELLE RINTZE MEINDERT,MADDEN KEVIN T,HARRISON JACOB C,TRUEHEART JOSHUA,GANCEDO RODRIGUEZ CARLOS,FLORES MAURIZ CARMEN-LISSET,BOWER STANLEY
- 优先权： US16301909 2009-03-24
- 主分类号： C12N1/15
- IPC分类号： C12N1/15 ; C12N15/54 ; C12P7/46 ; C12R1/66 ; C12R1/85
摘要：
Methods and recombinant microorganisms for the biological production of C4-dicarboxylic acids are described. The recombinant microorganisms have increased production of OAA as compared to unmodified microorganisms. In some cases, the recombinant microorganisms have been modified to reduce production of pyruvate and/or reduce conversion of pyruvate to acetaldehyde. Thus, the microorganisms are modified to reduce the activity of pyruvate kinase and/or pyruvate decarboxylase.
摘要（中）：
描述了用于生物生产C4-二羧酸的方法和重组微生物。 与未修饰的微生物相比，重组微生物具有增加的OAA产量。 在一些情况下，已经修饰了重组微生物以减少丙酮酸的产生和/或降低丙酮酸向乙醛的转化。 因此，修饰微生物以降低丙酮酸激酶和/或丙酮酸脱羧酶的活性。