发明申请
WO2010075584A1 METHODS OF DIAGNOSING AND PREDICTING CROHNS DISEASE FROM CHILDHOOD HYGIENE AND SEROLOGICAL PROFILES
审中-公开
基本信息:
- 专利标题： METHODS OF DIAGNOSING AND PREDICTING CROHNS DISEASE FROM CHILDHOOD HYGIENE AND SEROLOGICAL PROFILES
- 专利标题（中）：诊断和预测儿童卫生和流行病学概况的方法
- 申请号：PCT/US2009/069541 申请日：2009-12-24
- 公开(公告)号：WO2010075584A1 公开(公告)日：2010-07-01
- 发明人： ROTTER, Jerome, I. , TAYLOR, Kent, D. , TARGAN, Stephan, R.
- 申请人： CEDARS-SINAI MEDICAL CENTER , ROTTER, Jerome, I. , TAYLOR, Kent, D. , TARGAN, Stephan, R.
- 申请人地址： 8700 Beverly Boulevard Los Angeles, California 90048 US
- 专利权人： CEDARS-SINAI MEDICAL CENTER,ROTTER, Jerome, I.,TAYLOR, Kent, D.,TARGAN, Stephan, R.
- 当前专利权人： CEDARS-SINAI MEDICAL CENTER,ROTTER, Jerome, I.,TAYLOR, Kent, D.,TARGAN, Stephan, R.
- 当前专利权人地址： 8700 Beverly Boulevard Los Angeles, California 90048 US
- 代理机构： SENN, Sean et al.
- 优先权： US61/140,800 20081224
- 主分类号： G01N33/53
- IPC分类号： G01N33/53
摘要：
The present invention relates to the discovery that there is a different pathophysiology of inflammatory bowel disease in rural vs. urban areas. In one embodiment, a clean environment is positively associated with ASCA expression, but negatively associated with anti-OmpC and anti-I2 expression in subjects with Crohn's Disease. In another embodiment, the present invention provides a method of diagnosing susceptibility to Crohn's Disease in an individual by determining the presence or absence of risk factors, including serological profiles and sanitary conditions during the individual's childhood.
摘要（中）：
本发明涉及在农村与城市地区存在炎症性肠病的不同病理生理学的发现。 在一个实施方案中，清洁环境与ASCA表达正相关，但与克罗恩病患者的抗OmpC和抗I2表达呈负相关。 在另一个实施方案中，本发明提供了一种通过确定个体儿童期期间存在或不存在危险因素（包括血清学特征和卫生条件）来诊断个体中克罗恩病易感性的方法。