基本信息:
- 专利标题： ULTRA-HIGH MULTIPLEX ANALYTICAL SYSTEMS AND METHODS
- 专利标题（中）：超高分辨率分析系统和方法
- 申请号：PCT/US2009/005319 申请日：2009-09-25
- 公开(公告)号：WO2010039199A2 公开(公告)日：2010-04-08
- 发明人： ZACCARIN, Denis , LUNDQUIST, Paul , ZHAO, Peiqian , ZHONG, Frank , TURNER, Stephen , HUANG, Yanqiao , MONADGEMI, Pezhman , SAXENA, Ravi , GROT, Annette , RULISON, Aaron
- 申请人： PACIFIC BIOCIENCES OF CALIFORNIA, INC. , ZACCARIN, Denis , LUNDQUIST, Paul , ZHAO, Peiqian , ZHONG, Frank , TURNER, Stephen , HUANG, Yanqiao , MONADGEMI, Pezhman , SAXENA, Ravi , GROT, Annette , RULISON, Aaron
- 申请人地址： 1505 Adams Drive Menlo Park, CA 94025 US
- 专利权人： PACIFIC BIOCIENCES OF CALIFORNIA, INC.,ZACCARIN, Denis,LUNDQUIST, Paul,ZHAO, Peiqian,ZHONG, Frank,TURNER, Stephen,HUANG, Yanqiao,MONADGEMI, Pezhman,SAXENA, Ravi,GROT, Annette,RULISON, Aaron
- 当前专利权人： PACIFIC BIOCIENCES OF CALIFORNIA, INC.,ZACCARIN, Denis,LUNDQUIST, Paul,ZHAO, Peiqian,ZHONG, Frank,TURNER, Stephen,HUANG, Yanqiao,MONADGEMI, Pezhman,SAXENA, Ravi,GROT, Annette,RULISON, Aaron
- 当前专利权人地址： 1505 Adams Drive Menlo Park, CA 94025 US
- 代理机构： QUINE, Jonathan Alan et al.
- 优先权： US61/223,628 20090707; US61/101,555 20080930
- 主分类号： G02B6/12
- IPC分类号： G02B6/12 ; G01N21/00
摘要：
Apparatus, systems and methods for use in analyzing discrete reactions at ultra high multiplex with reduced optical noise, and increased system flexibility. Apparatus include substrates having integrated optical components that increase multiplex capability by one or more of increasing density of reaction regions, improving transmission of light to or collection of light from discrete reactions regions. Integrated optical components include reflective optical elements which re-direct illumination light and light emitted from the discrete regions to more efficiently collect emitted light. Particularly preferred applications include single molecule reaction analysis, such as polymerase mediated template dependent nucleic acid synthesis and sequence determination.
摘要（中）：
用于分析离散反应的设备，系统和方法，以超高的多重复用，降低光学噪声，提高系统灵活性。 装置包括具有集成光学部件的衬底，其通过一个或多个增加密度的反应区域增加多重能力，改善光从离散反应区域发射或收集光。 集成光学部件包括反射光学元件，其重新引导照明光和从离散区域发射的光以更有效地收集发射的光。 特别优选的应用包括单分子反应分析，例如聚合酶介导的模板依赖性核酸合成和序列测定。
IPC结构图谱:
| G | 物理 |
| --G02 | 光学 |
| ----G02B | 光学元件、系统或仪器 |
| ------G02B6/00 | 光导；包含光导和其他光学元件（如耦合器）的装置的结构零部件 |
| --------G02B6/02 | .带有包层的光导纤维 |
| ----------G02B6/12 | ..集成光路类型 |