发明申请
WO2010018130A1 PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES
审中-公开
基本信息:
- 专利标题： PURINE DERIVATIVES FOR USE IN THE TREATMENT OF ALLERGIC, INFLAMMATORY AND INFECTIOUS DISEASES
- 专利标题（中）：用于治疗过敏，炎性和感染性疾病的药物衍生物
- 申请号：PCT/EP2009/060262 申请日：2009-08-07
- 公开(公告)号：WO2010018130A1 公开(公告)日：2010-02-18
- 发明人： CAMPOS, Sebastien, Andre , COE, Diane, Mary , TRIVEDI, Naimisha
- 申请人： SMITHKLINE BEECHAM CORPORATION , CAMPOS, Sebastien, Andre , COE, Diane, Mary , TRIVEDI, Naimisha
- 申请人地址： One Franklin Plaza Po Box 7929 Philadelphia, Pennsylvania 19101 US
- 专利权人： SMITHKLINE BEECHAM CORPORATION,CAMPOS, Sebastien, Andre,COE, Diane, Mary,TRIVEDI, Naimisha
- 当前专利权人： SMITHKLINE BEECHAM CORPORATION,CAMPOS, Sebastien, Andre,COE, Diane, Mary,TRIVEDI, Naimisha
- 当前专利权人地址： One Franklin Plaza Po Box 7929 Philadelphia, Pennsylvania 19101 US
- 代理机构： POVEY, Alexander, William, George et al.
- 优先权： US61/087,785 20080811
- 主分类号： C07D473/16
- IPC分类号： C07D473/16 ; C07D473/18 ; A61K31/522 ; A61P35/00 ; A61P37/00
摘要：
Compounds of formula (I): wherein R 1 is C 1-6 alkylamino, or C 1-6 alkoxy; m is an integer having a value of 3, 4, or 5; n is an integer having a value of 0 to 3; p is an integer having a value of 1 or 2 and salts thereof are inducers of human interferon. Compounds which induce human interferon may be useful in the treatment of various disorders, for example the treatment of allergic diseases and other inflammatory conditions for example allergic rhinitis and asthma, the treatment of infectious diseases and cancer, and may also be useful as vaccine adjuvants.
摘要（中）：
式（I）的化合物：其中R 1是C 1-6烷基氨基或C 1-6烷氧基; m是值为3,4或5的整数; n为0〜3的整数， p是值为1或2的整数，其盐是人类干扰素的诱导剂。 诱导人类干扰素的化合物可用于治疗各种疾病，例如治疗过敏性疾病和其它炎性病症，例如过敏性鼻炎和哮喘，治疗感染性疾病和癌症，并且也可用作疫苗佐剂。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D473/00 | 含嘌呤环系的杂环化合物 |
| --------C07D473/02 | .有氧、硫或氮原子直接连在位置2和6 |
| ----------C07D473/16 | ..两个氮原子 |