基本信息:
- 专利标题: ANTAGONISTS OF PROSTAGLANDIN D2 RECEPTORS
- 专利标题(中):前列腺素D2受体的拮抗剂
- 申请号:PCT/US2009/049621 申请日:2009-07-02
- 公开(公告)号:WO2010003120A2 公开(公告)日:2010-01-07
- 发明人: HUTCHINSON, John, Howard , SEIDERS, Thomas, Jon , WANG, Bowei , ARRUDA, Jeannie, M. , STEARNS, Brian, Andrew
- 申请人: AMIRA PHARMACEUTICALS, INC. , HUTCHINSON, John, Howard , SEIDERS, Thomas, Jon , WANG, Bowei , ARRUDA, Jeannie, M. , STEARNS, Brian, Andrew
- 申请人地址: 9535 Waples Street Suite 100 San Diego, CA 92121 US
- 专利权人: AMIRA PHARMACEUTICALS, INC.,HUTCHINSON, John, Howard,SEIDERS, Thomas, Jon,WANG, Bowei,ARRUDA, Jeannie, M.,STEARNS, Brian, Andrew
- 当前专利权人: AMIRA PHARMACEUTICALS, INC.,HUTCHINSON, John, Howard,SEIDERS, Thomas, Jon,WANG, Bowei,ARRUDA, Jeannie, M.,STEARNS, Brian, Andrew
- 当前专利权人地址: 9535 Waples Street Suite 100 San Diego, CA 92121 US
- 代理机构: AKHAVAN, Ramin et al.
- 优先权: US61/078,311 20080703
- 主分类号: C07C323/57
- IPC分类号: C07C323/57 ; C07C321/20 ; A61K31/167 ; A61K31/10 ; A61P11/00 ; A61P37/08
摘要:
Described herein are compounds that are antagonists of PGD 2 receptors. Also described are pharmaceutical compositions that include the compounds described herein, and methods of using such antagonists of PGD 2 receptors, alone or in combination with other compounds, for treating respiratory, cardiovascular, and other PGD 2 -dependent or PGD 2 -mediated conditions or diseases.
摘要(中):
本文描述的是作为PGDα2受体拮抗剂的化合物。 还描述了包含本文所述化合物的药物组合物以及单独或与其它化合物组合使用PGD 2受体拮抗剂用于治疗呼吸系统疾病,心血管疾病和其他PGD 2受体的药物组合物, 2依赖性或PGD 2介导的病症或疾病。 p>
IPC结构图谱:
C | 化学;冶金 |
--C07 | 有机化学 |
----C07C | 无环或碳环化合物 |
------C07C323/00 | 被卤素、氧或氮原子或非硫代基硫原子取代的硫醇、硫醚、氢化多硫化物或多硫化物 |
--------C07C323/23 | .硫代基和不属于硝基或亚硝基氮原子连接在同一碳架上 |
----------C07C323/51 | ..有硫代基的硫原子连接在碳架的非环碳原子上 |
------------C07C323/57 | ...碳架进一步被不属于硝基或亚硝基的氮原子取代 |