基本信息:
- 专利标题： TGF-B ANTAGONIST MULTI-TARGET BINDING PROTEINS
- 专利标题（中）：TGF-B拮抗剂多靶标结合蛋白
- 申请号：PCT/US2009/049616 申请日：2009-07-02
- 公开(公告)号：WO2010003118A1 公开(公告)日：2010-01-07
- 发明人： LOFQUIST, Alan, Keith , BAUM, Peter, Robert , THOMPSON, Peter, Armstrong , MISHER, Lynda
- 申请人： TRUBION PHARMACEUTICALS, INC. , LOFQUIST, Alan, Keith , BAUM, Peter, Robert , THOMPSON, Peter, Armstrong , MISHER, Lynda
- 申请人地址： 2401 Fourth Avenue, Suite 1050 Seattle, WA 98121 US
- 专利权人： TRUBION PHARMACEUTICALS, INC.,LOFQUIST, Alan, Keith,BAUM, Peter, Robert,THOMPSON, Peter, Armstrong,MISHER, Lynda
- 当前专利权人： TRUBION PHARMACEUTICALS, INC.,LOFQUIST, Alan, Keith,BAUM, Peter, Robert,THOMPSON, Peter, Armstrong,MISHER, Lynda
- 当前专利权人地址： 2401 Fourth Avenue, Suite 1050 Seattle, WA 98121 US
- 代理机构： SLEATH, Janet et al.
- 优先权： US61/134,091 20080702; US61/134,090 20080702; US61/134,089 20080702; US61/134,088 20080702; US61/134,085 20080702; US61/134,087 20080702; US61/134,086 20080702; US61/181,232 20090526
- 主分类号： C12N15/62
- IPC分类号： C12N15/62 ; C07K14/715 ; C07K16/28 ; C07K16/24 ; A61K38/17
摘要：
This disclosure provides a multi-target fusion protein composed of a TGF? antagonist domain and another binding domain antagonistic for a heterologous target (such as IL6, IL10, VEGF, TNF, HGF, TWEAK, IGF) or agonistic for a heterologous target (such as GITR). The multi-specific fusion protein may also include an intervening domain that separates the binding domains and allows for dimerization. This disclosure also provides polynucleotides encoding the multi-specific fusion proteins, compositions of the fusion proteins, and methods of using the multi-specific fusion proteins and compositions.
摘要（中）：
本公开提供了由TGFβ1组成的多靶融合蛋白， 拮抗剂结构域和对异源靶标（如IL6，IL10，VEGF，TNF，HGF，TWEAK，IGF）拮抗的另一结合结构域或对异源靶标（如GITR）的激动作用。 多特异性融合蛋白还可以包括分离结合域并允许二聚化的中间结构域。 本公开还提供了编码多特异融合蛋白的多核苷酸，融合蛋白的组合物，以及使用多特异性融合蛋白和组合物的方法。