基本信息:
- 专利标题： PYRAZOLE DERIVATIVES USEFUL AS INHIBITORS OF FAAH
- 专利标题（中）：作为FAAH的抑制剂有用的吡唑衍生物
- 申请号：PCT/US2009/045823 申请日：2009-06-01
- 公开(公告)号：WO2009151991A1 公开(公告)日：2009-12-17
- 发明人： LIN, Linus, S. , CHANG, Linda, L. , CHOBANIAN, Harry , NARGUND, Ravi, P.
- 申请人： MERCK & CO., INC. , LIN, Linus, S. , CHANG, Linda, L. , CHOBANIAN, Harry , NARGUND, Ravi, P.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK & CO., INC.,LIN, Linus, S.,CHANG, Linda, L.,CHOBANIAN, Harry,NARGUND, Ravi, P.
- 当前专利权人： MERCK & CO., INC.,LIN, Linus, S.,CHANG, Linda, L.,CHOBANIAN, Harry,NARGUND, Ravi, P.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK & CO., INC.
- 优先权： US61/131,636 20080611
- 主分类号： A01N43/56
- IPC分类号： A01N43/56 ; A61K31/415
摘要：
The present invention is directed to certain imidazole derivatives which are useful as inhibitors of Fatty Acid Amide Hydrolase (FAAH). The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including osteoarthritis, rheumatoid arthritis, diabetic neuropathy, postherpetic neuralgia, skeletomuscular pain, and fibromyalgia, as well as acute pain, migraine, sleep disorder, Alzheimer disease, and Parkinson's disease
摘要（中）：
本发明涉及可用作脂肪酸酰胺水解酶（FAAH）抑制剂的某些咪唑衍生物。 本发明还涉及包含这些化合物作为活性成分的药物制剂，以及这些化合物及其制剂在治疗某些障碍（包括骨关节炎，类风湿性关节炎，糖尿病性神经病变，带状疱疹后神经痛，ke肉肌痛和纤维肌痛）中的用途以及 作为急性疼痛，偏头痛，睡眠障碍，阿尔茨海默病和帕金森病