基本信息:
- 专利标题： TRIAZINE COMPOUNDS AS P13 KINASE AND MTOR INHIBITORS
- 专利标题（中）：TRIAZINE化合物作为P13激酶和MT抑制剂
- 申请号：PCT/US2009/044774 申请日：2009-05-21
- 公开(公告)号：WO2009143313A1 公开(公告)日：2009-11-26
- 发明人： VENKATESAN, Aranapakam, M. , CHEN, Zecheng , DEHNHARDT, Christoph, M. , DOS SANTOS, Osvaldo , DELOS SANTOS, Efren Guillermo , ZASK, Arie , VERHEIJEN, Jeroen, C. , KAPLAN, Joshua, Aaron , RICHARD, David, J. , AYRAL-KALOUSTIAN, Semiramis , MANSOUR, Tarek, S. , GOPALSAMY, Ariamala , CURRAN, Kevin, J. , SHI, Mengxiao
- 申请人： WYETH , VENKATESAN, Aranapakam, M. , CHEN, Zecheng , DEHNHARDT, Christoph, M. , DOS SANTOS, Osvaldo , DELOS SANTOS, Efren Guillermo , ZASK, Arie , VERHEIJEN, Jeroen, C. , KAPLAN, Joshua, Aaron , RICHARD, David, J. , AYRAL-KALOUSTIAN, Semiramis , MANSOUR, Tarek, S. , GOPALSAMY, Ariamala , CURRAN, Kevin, J. , SHI, Mengxiao
- 申请人地址： Patent Law Department Five Giralda Farms Madison, NJ 07940 US
- 专利权人： WYETH,VENKATESAN, Aranapakam, M.,CHEN, Zecheng,DEHNHARDT, Christoph, M.,DOS SANTOS, Osvaldo,DELOS SANTOS, Efren Guillermo,ZASK, Arie,VERHEIJEN, Jeroen, C.,KAPLAN, Joshua, Aaron,RICHARD, David, J.,AYRAL-KALOUSTIAN, Semiramis,MANSOUR, Tarek, S.,GOPALSAMY, Ariamala,CURRAN, Kevin, J.,SHI, Mengxiao
- 当前专利权人： WYETH,VENKATESAN, Aranapakam, M.,CHEN, Zecheng,DEHNHARDT, Christoph, M.,DOS SANTOS, Osvaldo,DELOS SANTOS, Efren Guillermo,ZASK, Arie,VERHEIJEN, Jeroen, C.,KAPLAN, Joshua, Aaron,RICHARD, David, J.,AYRAL-KALOUSTIAN, Semiramis,MANSOUR, Tarek, S.,GOPALSAMY, Ariamala,CURRAN, Kevin, J.,SHI, Mengxiao
- 当前专利权人地址： Patent Law Department Five Giralda Farms Madison, NJ 07940 US
- 代理机构： MC KENZIE, Thomas et al.
- 优先权： US61/055,661 20080523
- 主分类号： C07D498/08
- IPC分类号： C07D498/08 ; A61K31/53 ; A61P35/00
摘要：
Compounds of formula I (I) wherein: R 1 is (II) or (III); and R 2 , R 4 , and R 6-9 are defined herein, and pharmaceutically acceptable salts and esters thereof. These compounds inhibit PI3 kinase and mTOR, and may be used to treat diseases mediated by PI3 kinase and mTOR, such as a variety of cancers. Methods for making and using the compounds of this invention are disclosed. Various compositions containing the compounds of this invention are also disclosed.
摘要（中）：
式I（I）的化合物，其中：R 1是（II）或（III）; 并且R 2，R 4和R 6-9在本文中定义，及其药学上可接受的盐和酯。 这些化合物抑制PI3激酶和mTOR，并可用于治疗PI3激酶和mTOR介导的疾病，如多种癌症。 公开了制备和使用本发明化合物的方法。 还公开了含有本发明化合物的各种组合物。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D498/00 | 杂环化合物，在稠环系中至少有1个杂环具有氮和氧原子作为仅有的杂环原子 |
| --------C07D498/02 | .在稠环系中含有两个杂环 |
| ----------C07D498/08 | ..桥系 |