发明申请
WO2009127944A8 ETHER BENZYLIDENE PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS
审中-公开
基本信息:
- 专利标题： ETHER BENZYLIDENE PIPERIDINE ARYL CARBOXAMIDE COMPOUNDS USEFUL AS FAAH INHIBITORS
- 申请号：PCT/IB2009/005246 申请日：2009-04-09
- 公开(公告)号：WO2009127944A8 公开(公告)日：2009-10-22
- 发明人： FAY, Lorraine Kathleen , JOHNSON, Douglas Scott , MEYERS, Marvin Jay , THORARENSEN, Atli , WANG, Lijuan Jane
- 申请人： PFIZER INC. , FAY, Lorraine Kathleen , JOHNSON, Douglas Scott , MEYERS, Marvin Jay , THORARENSEN, Atli , WANG, Lijuan Jane
- 申请人地址： 235 East 42nd Street New York, NY 10017 US
- 专利权人： PFIZER INC.,FAY, Lorraine Kathleen,JOHNSON, Douglas Scott,MEYERS, Marvin Jay,THORARENSEN, Atli,WANG, Lijuan Jane
- 当前专利权人： PFIZER INC.,FAY, Lorraine Kathleen,JOHNSON, Douglas Scott,MEYERS, Marvin Jay,THORARENSEN, Atli,WANG, Lijuan Jane
- 当前专利权人地址： 235 East 42nd Street New York, NY 10017 US
- 代理机构： RICHARDSON, Peter, C.
- 优先权： US61/045,899 20080417
- 主分类号： C07D211/70
- IPC分类号： C07D211/70 ; C07D401/12 ; C07D413/12 ; A61K31/4427 ; A61P29/00 ; A61P25/00 ; A61P9/00
摘要：
The present invention relates to compounds of Formula (I) wherein Ar is optionally substituted phenyl or 6-membered heteroaryl moiety, or a benzisoxazole, pyrrolopyridine, or benzotriazole group; or a pharmaceutically acceptable salt thereof; processes for the preparation of the compounds; intermediates used in the preparation of the compounds; compositions containing the compounds; and uses of the compounds in treating diseases or conditions associated with fatty acid amide hydrolase (FAAH) activity, including pain, urinary incontinence, overactive bladder, emesis, cognitive disorders, anxiety, depression, sleeping disorders, eating disorders, movement disorders, glaucoma, psoriasis, multiple sclerosis, cerebrovascular disorders, brain injury, gastrointestinal disorders, hypertension, or cardiovascular disease.
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D211/00 | 杂环化合物，含氢化吡啶环，不与其他环稠合 |
| --------C07D211/04 | .只有氢或碳原子直接连在环氮原子上 |
| ----------C07D211/06 | ..环原子间或环原子与非环原子间无双键 |
| ------------C07D211/70 | ...只有氢原子、烃基或取代的烃基，直接连在环碳原子上 |