A transdermal micro -patch (1) for use with living tissue (19) is provided. The micro -patch (1) includes a first membrane (9), a reservoir (3), a micro -pump (4), flextensional transducers (2), a microelectronics circuit (5), and an optional sensor (27). The first membrane (9) is permeable to allow the passage of fluid (1 8) in either a unidirectional or bidirectional fashion. The reservoir (3) is a container -like element capable of storing a fluid (19) removed from or communicated into the tissue (19). The micro -pump (4) facilitates transport of the fluid (1 8) between the reservoir (3) and first membrane (9). The flextensional transducers (2) generate ultrasonic waves (15) which are separately communicated into the tissue (19) to transport fluid (18) between the first membrane (9) and tissue (19). Ultrasonic waves (15) could interact to enhance the performance of the micro-patch (1). The microelectronics circuit (5) controls both flextensional transducers (2) and the micro -pump (4). The sensor (27) could be embedded within the micro -patch (1) to monitor temperature, pressure, or flow rate so as to avoid damage or irritation to the tissue (19).