基本信息:
- 专利标题： ANTIGENIC CLOAKING AND ITS USE
- 专利标题（中）：抗原克隆及其使用
- 申请号：PCT/US2009/033457 申请日：2009-02-06
- 公开(公告)号：WO2009100376A2 公开(公告)日：2009-08-13
- 发明人： KWONG, Peter, D. , NABEL, Gary, J. , SHAW, George , SCHIEF, William , YANG, Zhi-yong , ZHOU, Tongqing , CHEN, Lei , KWON, Young Do
- 申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES , UNIVERSITY OF WASHINGTON , UNIVERSITY OF ALABAMA AT BIRMINGHAM , KWONG, Peter, D. , NABEL, Gary, J. , SHAW, George , SCHIEF, William , YANG, Zhi-yong , ZHOU, Tongqing , CHEN, Lei , KWON, Young Do
- 申请人地址： National Institutes Of Health Office Of Technology Transfer 6011 Executive Blvd., Suite 325 Rockville, MD 20852-3804 US
- 专利权人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES,UNIVERSITY OF WASHINGTON,UNIVERSITY OF ALABAMA AT BIRMINGHAM,KWONG, Peter, D.,NABEL, Gary, J.,SHAW, George,SCHIEF, William,YANG, Zhi-yong,ZHOU, Tongqing,CHEN, Lei,KWON, Young Do
- 当前专利权人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES,UNIVERSITY OF WASHINGTON,UNIVERSITY OF ALABAMA AT BIRMINGHAM,KWONG, Peter, D.,NABEL, Gary, J.,SHAW, George,SCHIEF, William,YANG, Zhi-yong,ZHOU, Tongqing,CHEN, Lei,KWON, Young Do
- 当前专利权人地址： National Institutes Of Health Office Of Technology Transfer 6011 Executive Blvd., Suite 325 Rockville, MD 20852-3804 US
- 代理机构： GRISWOLD, Ian, J.
- 优先权： US61/065,114 20080207; US61/065,896 20080214
- 主分类号： A61K39/21
- IPC分类号： A61K39/21 ; C12N15/49 ; G06F19/00
摘要：
Disclosed are antigens that include a target epitope that is defined by atomic coordinates of those amino acids of the antigen that contact an antibody of interest that specifically binds the antigen. The disclosed antigens have between about 10% and about 90% of surface exposed amino acid residues located exterior of the target epitope substituted as compared to a wild- type antigen and less than about 10% of the non-surface exposed amino acid residues substituted as compared to a wild-type antigen. Also disclosed are nucleic acids encoding these antigens and methods of producing these antigens. Methods for generating an immune response in a subject are also disclosed. In some embodiments, the method is a method for treating or preventing a human immunodeficiency type 1 (HIV-I) infection in a subject.
摘要（中）：
公开的是包含由与抗原特异性结合的目的抗体接触的抗原的那些氨基酸的原子坐标定义的靶表位的抗原。 与野生型抗原相比，所公开的抗原具有位于目标表位外部的表面暴露的氨基酸残基的约10％至约90％，并且少于约10％的非表面暴露的氨基酸残基被取代为 与野生型抗原相比。 还公开了编码这些抗原的核酸和产生这些抗原的方法。 还公开了在受试者中产生免疫应答的方法。 在一些实施方案中，该方法是用于治疗或预防受试者中的人类免疫缺陷1型（HIV-1）感染的方法。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K39/00 | 含有抗原或抗体的医药配制品 |
| --------A61K39/12 | .病毒性抗原 |
| ----------A61K39/21 | ..反录病毒科，例如马染性贫血病毒 |