基本信息:
- 专利标题: COMPOSITIONS AND METHODS FOR ADOPTIVE AND ACTIVE IMMUNOTHERAPY
- 专利标题(中):用于自主和主动免疫治疗的组合物和方法
- 申请号:PCT/US2009/030966 申请日:2009-01-14
- 公开(公告)号:WO2009094273A2 公开(公告)日:2009-07-30
- 发明人: FAHMY, Tarek , STEENBLOCK, Erin
- 申请人: YALE UNIVERSITY , FAHMY, Tarek , STEENBLOCK, Erin
- 申请人地址: 433 Temple Street, 1st Floor New Haven, CT 06511 US
- 专利权人: YALE UNIVERSITY,FAHMY, Tarek,STEENBLOCK, Erin
- 当前专利权人: YALE UNIVERSITY,FAHMY, Tarek,STEENBLOCK, Erin
- 当前专利权人地址: 433 Temple Street, 1st Floor New Haven, CT 06511 US
- 代理机构: PABST, Patrea, L.
- 优先权: US61/021,258 20080115
- 主分类号: A61K39/00
- IPC分类号: A61K39/00
摘要:
Modular aAPCs and methods of their manufacture and use are provided. The modular aAPCs are constructed from polymeric microparticles. The aAPCs include encapsulated cytokines and coupling agents which modularly couple functional elements including T cell receptor activators, co-stimulatory molecules and adhesion molecules to the particle. The ability of these aAPCs to release cytokines in a controlled manner, coupled with their modular nature and ease of ligand attachment, results in an ideal, tunable APC capable of stimulating and expanding primary T cells.
摘要(中):
提供了模块化的aAPC及其制造和使用方法。 模块化的aAPCs由聚合物微粒构成。 aAPCs包括封装的细胞因子和偶联剂,其将包括T细胞受体激活剂,共刺激分子和粘附分子的功能元件模块化地偶联到颗粒。 这些aAPCs以受控的方式释放细胞因子以及其模块化性质和配体附着的容易性的能力导致能够刺激和扩增原代T细胞的理想的可调节APC。
IPC结构图谱:
A | 人类生活必需 |
--A61 | 医学或兽医学;卫生学 |
----A61K | 医用、牙科用或梳妆用的配制品 |
------A61K39/00 | 含有抗原或抗体的医药配制品 |