基本信息:
- 专利标题： STILBENE DERIVATIVES AS PSTAT3/IL-6 INHIBITORS
- 专利标题（中）：酪氨酸衍生物作为PSTAT3 / IL-6抑制剂
- 申请号：PCT/IB2008/002943 申请日：2008-11-04
- 公开(公告)号：WO2009060282A2 公开(公告)日：2009-05-14
- 发明人： RAJAGOPAL, Sridharan , SELVAKUMAR, Thangapazham , BHARATHIMOHAN, Kuppusamy , KACHHADIA, Virendra , RAJAGOPAL, Sriram , PRAVEEN, Rajendran , BALAJI, Ramachandran
- 申请人： ORCHID RESEARCH LABORATORIES LIMITED , RAJAGOPAL, Sridharan , SELVAKUMAR, Thangapazham , BHARATHIMOHAN, Kuppusamy , KACHHADIA, Virendra , RAJAGOPAL, Sriram , PRAVEEN, Rajendran , BALAJI, Ramachandran
- 申请人地址： Orchid Towers 313, Valluvar Kottam High Road Nungambakkam Chennai 600 034 IN
- 专利权人： ORCHID RESEARCH LABORATORIES LIMITED,RAJAGOPAL, Sridharan,SELVAKUMAR, Thangapazham,BHARATHIMOHAN, Kuppusamy,KACHHADIA, Virendra,RAJAGOPAL, Sriram,PRAVEEN, Rajendran,BALAJI, Ramachandran
- 当前专利权人： ORCHID RESEARCH LABORATORIES LIMITED,RAJAGOPAL, Sridharan,SELVAKUMAR, Thangapazham,BHARATHIMOHAN, Kuppusamy,KACHHADIA, Virendra,RAJAGOPAL, Sriram,PRAVEEN, Rajendran,BALAJI, Ramachandran
- 当前专利权人地址： Orchid Towers 313, Valluvar Kottam High Road Nungambakkam Chennai 600 034 IN
- 代理机构： TIWARI, Amrish et al.
- 优先权： IN2548/CHE/2007 20071106; IN1165/CHE/2008 20080513
- 主分类号： C07C217/04
- IPC分类号： C07C217/04 ; C07C213/00 ; A61K31/221
摘要：
Described are novel compounds of the formula (I), their derivatives, analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, intermediates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These novel compounds can inhibit pSTAT3/IL-6 and are useful as a therapeutic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, autoimmune diseases, skin diseases, infections, inflammation, etc.
摘要（中）：
描述了式（I）的新化合物，其衍生物，类似物，互变异构形式，立体异构体，多晶型物，水合物，溶剂合物，中间体，药学上可接受的盐，药物组合物，代谢物和前药。 这些新型化合物可以抑制pSTAT3 / IL-6，并且可用作涉及细胞生长的疾病如恶性肿瘤，自身免疫性疾病，皮肤病，感染，炎症等的治疗或改善剂。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07C | 无环或碳环化合物 |
| ------C07C217/00 | 连接在同一个碳架上的含氨基和醚化的羟基的化合物 |
| --------C07C217/02 | .醚化的羟基和氨基连接在同一个碳架的非环碳原子上 |
| ----------C07C217/04 | ..碳架是无环和饱和的 |