发明申请
WO2009009768A8 METHODS OF INHIBITING THE FORMATION OF AMYLOID-ß DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUNDS
审中-公开
基本信息:
- 专利标题： METHODS OF INHIBITING THE FORMATION OF AMYLOID-ß DIFFUSABLE LIGANDS USING A ACYLHYDRAZIDE COMPOUNDS
- 专利标题（中）：使用氰基化合物抑制AMYLOID-β可扩散配体形成的方法
- 申请号：PCT/US2008069878 申请日：2008-07-11
- 公开(公告)号：WO2009009768A8 公开(公告)日：2010-01-28
- 发明人： LOOK GARY CHARLES , SCHULTZ LAURI , POLOZOV ALEXANDRE MIKHAYLOVICH , BHAGAT NIKHIL , WANG JIAN , ZEMBOWER DAVID E , GOURE WILLIAM F , PRAY TODD , KRAFFT GRANT A
- 申请人： ACUMEN PHARMACEUTICALS INC , LOOK GARY CHARLES , SCHULTZ LAURI , POLOZOV ALEXANDRE MIKHAYLOVICH , BHAGAT NIKHIL , WANG JIAN , ZEMBOWER DAVID E , GOURE WILLIAM F , PRAY TODD , KRAFFT GRANT A
- 专利权人： ACUMEN PHARMACEUTICALS INC,LOOK GARY CHARLES,SCHULTZ LAURI,POLOZOV ALEXANDRE MIKHAYLOVICH,BHAGAT NIKHIL,WANG JIAN,ZEMBOWER DAVID E,GOURE WILLIAM F,PRAY TODD,KRAFFT GRANT A
- 当前专利权人： ACUMEN PHARMACEUTICALS INC,LOOK GARY CHARLES,SCHULTZ LAURI,POLOZOV ALEXANDRE MIKHAYLOVICH,BHAGAT NIKHIL,WANG JIAN,ZEMBOWER DAVID E,GOURE WILLIAM F,PRAY TODD,KRAFFT GRANT A
- 优先权： US77726407 2007-07-12; US77726607 2007-07-12; US95072407 2007-07-19; US95081007 2007-07-19
- 主分类号： A61K31/15
- IPC分类号： A61K31/15 ; A61P9/10 ; A61P25/28
摘要：
Disclosed are methods of inhibiting, regulating, and/or modulating the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ß1-42 oligomers from amyloid ß1-42 monomers using acylhydrazidecompounds. Also disclosed are methods of treating a patient suffering from diseases associated with the formation of soluble, globular, non-fibrillar, neurotoxic amyloid ß1-42 oligomers using acylhydrazidecompounds.
摘要（中）：
公开了使用酰肼化合物从淀粉样蛋白β1-42单体抑制，调节和/或调节可溶性，球状，非纤维状，神经毒性淀粉样蛋白β1-42寡聚体形成的方法。 还公开了治疗患有与使用酰肼化合物形成可溶性，球状，非纤维状，神经毒性淀粉样蛋白β1-42寡聚物相关的疾病的患者的方法。
公开/授权文献:
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/045 | .羟基化合物，例如醇类；其盐类，例如醇化物 |
| ----------A61K31/15 | ..肟CON；肼NN；腙NN |