基本信息:
- 专利标题： SUBSTITUTED PIPERAZINES AS CB1 ANTAGONISTS
- 专利标题（中）：取代的哌嗪作为CB1拮抗剂
- 申请号：PCT/US2008/007868 申请日：2008-06-25
- 公开(公告)号：WO2009005646A2 公开(公告)日：2009-01-08
- 发明人： GILBERT, Eric, J. , MILLER, Michael, W. , SCOTT, Jack, D. , DEMONG, Duane, Eugene , STAMFORD, Andrew , GREENLEE, William, J. , CELLY, Chander, Shekher
- 申请人： SCHERING CORPORATION , GILBERT, Eric, J. , MILLER, Michael, W. , SCOTT, Jack, D. , DEMONG, Duane, Eugene , STAMFORD, Andrew , GREENLEE, William, J. , CELLY, Chander, Shekher
- 申请人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 专利权人： SCHERING CORPORATION,GILBERT, Eric, J.,MILLER, Michael, W.,SCOTT, Jack, D.,DEMONG, Duane, Eugene,STAMFORD, Andrew,GREENLEE, William, J.,CELLY, Chander, Shekher
- 当前专利权人： SCHERING CORPORATION,GILBERT, Eric, J.,MILLER, Michael, W.,SCOTT, Jack, D.,DEMONG, Duane, Eugene,STAMFORD, Andrew,GREENLEE, William, J.,CELLY, Chander, Shekher
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 代理机构： MACMILLAN, Keith
- 优先权： US60/946,873 20070628
- 主分类号： C07D241/04
- IPC分类号： C07D241/04 ; C07D401/06 ; C07D401/14 ; C07D403/12 ; C07D403/14 ; A61K31/496 ; A61K31/506 ; A61P3/00 ; A61P9/10
摘要：
Compounds of Formula (I) or pharmaceutically acceptable salts, solvates, or esters thereof, are useful in treating diseases or conditions mediated by CB 1 receptors, such as metabolic syndrome and obesity, neuroinflammatory disorders, cognitive disorders and psychosis, addiction (e.g., smoking cessation), gastrointestinal disorders, and cardiovascular conditions.
摘要（中）：
式（I）化合物或其药学上可接受的盐，溶剂化物或酯可用于治疗由CB 1受体介导的疾病或病症，例如代谢综合征和 肥胖症，神经炎性疾病，认知障碍和精神病，成瘾（例如戒烟），胃肠疾病和心血管疾病。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D241/00 | 杂环化合物，含1,4-二嗪环或氢化1,4-二嗪环 |
| --------C07D241/02 | .不与其他环稠合 |
| ----------C07D241/04 | ..环原子间或环原子与非环原子间无双键 |