基本信息:
- 专利标题： RENIN INHIBITORS
- 申请号：PCT/US2008/059384 申请日：2008-04-04
- 公开(公告)号：WO2008124575A8 公开(公告)日：2008-10-16
- 发明人： BALDWIN, John, J. , CACATIAN, Salvacion , CLAREMON, David , DILLARD, Lawrence, W. , FLAHERTY, Patrick, T. , GHAVIMI-ALAGHA, Bahman , GHIRLANDA, Damiano , ISHCHENKO, Alexey, V. , KALLANDER, Lara, S. , LAWHORN, Brian , LEACH, Colin, A. , LU, Qing , MCGEEHAN, Gerald , PATTERSON, Jaclyn, R. , SIMPSON, Robert, D. , SINGH, Suresh, B. , STOY, Patrick , TERRELL, Lamont, R. , TICE, Colin , XU, Zhenrong , YUAN, Jing , YUAN, Catherine, C., K. , ZHANG, Jing , ZHAO, Wei
- 申请人： VITAE PHARMACEUTICALS, INC. , BALDWIN, John, J. , CACATIAN, Salvacion , CLAREMON, David , DILLARD, Lawrence, W. , FLAHERTY, Patrick, T. , GHAVIMI-ALAGHA, Bahman , GHIRLANDA, Damiano , ISHCHENKO, Alexey, V. , KALLANDER, Lara, S. , LAWHORN, Brian , LEACH, Colin, A. , LU, Qing , MCGEEHAN, Gerald , PATTERSON, Jaclyn, R. , SIMPSON, Robert, D. , SINGH, Suresh, B. , STOY, Patrick , TERRELL, Lamont, R. , TICE, Colin , XU, Zhenrong , YUAN, Jing , YUAN, Catherine, C., K. , ZHANG, Jing , ZHAO, Wei
- 申请人地址： 502 West Office Center Drive Fort Washington, PA 19034 US
- 专利权人： VITAE PHARMACEUTICALS, INC.,BALDWIN, John, J.,CACATIAN, Salvacion,CLAREMON, David,DILLARD, Lawrence, W.,FLAHERTY, Patrick, T.,GHAVIMI-ALAGHA, Bahman,GHIRLANDA, Damiano,ISHCHENKO, Alexey, V.,KALLANDER, Lara, S.,LAWHORN, Brian,LEACH, Colin, A.,LU, Qing,MCGEEHAN, Gerald,PATTERSON, Jaclyn, R.,SIMPSON, Robert, D.,SINGH, Suresh, B.,STOY, Patrick,TERRELL, Lamont, R.,TICE, Colin,XU, Zhenrong,YUAN, Jing,YUAN, Catherine, C., K.,ZHANG, Jing,ZHAO, Wei
- 当前专利权人： VITAE PHARMACEUTICALS, INC.,BALDWIN, John, J.,CACATIAN, Salvacion,CLAREMON, David,DILLARD, Lawrence, W.,FLAHERTY, Patrick, T.,GHAVIMI-ALAGHA, Bahman,GHIRLANDA, Damiano,ISHCHENKO, Alexey, V.,KALLANDER, Lara, S.,LAWHORN, Brian,LEACH, Colin, A.,LU, Qing,MCGEEHAN, Gerald,PATTERSON, Jaclyn, R.,SIMPSON, Robert, D.,SINGH, Suresh, B.,STOY, Patrick,TERRELL, Lamont, R.,TICE, Colin,XU, Zhenrong,YUAN, Jing,YUAN, Catherine, C., K.,ZHANG, Jing,ZHAO, Wei
- 当前专利权人地址： 502 West Office Center Drive Fort Washington, PA 19034 US
- 代理机构： SIEBURTH, Kathryn, L. et al.
- 优先权： US60/910,221 20070405
- 主分类号： A01N35/00
- IPC分类号： A01N35/00 ; A61K31/10 ; A61K31/12
摘要：
Disclosed are compounds of Formula (I) wherein the R, R 1 , R 2 , R 3 , X, Y, A, Q, E, and G are defined herein. These compounds bind to aspartic proteases to inhibit their activity and are useful in the treatment or amelioration of diseases associated with aspartic protease activity. Also disclosed are methods of use of the compounds of Formula I for ameliorating or treating aspartic protease related disorders in a subject in need thereof.