发明申请
WO2008117199A2 ANIMAL MODEL, SYSTEM, AND METHOD FOR SCREENING COMPOUNDS FOR ANTITHROMBOTIC AND/OR THROMBOLYTIC ACTIVITY
审中-公开
基本信息:
- 专利标题： ANIMAL MODEL, SYSTEM, AND METHOD FOR SCREENING COMPOUNDS FOR ANTITHROMBOTIC AND/OR THROMBOLYTIC ACTIVITY
- 专利标题（中）：动物模型，系统和筛选化合物用于抗血栓形成和/或血栓形成活性的方法
- 申请号：PCT/IB2008/051010 申请日：2008-03-18
- 公开(公告)号：WO2008117199A2 公开(公告)日：2008-10-02
- 发明人： GUPTE, Ravindra, Dattatraya , TANNU, Aditi, Amol , PANICKER, Radha, Bhaskar , SHARMA, Somesh
- 申请人： PIRAMAL LIFE SCIENCES LIMITED , GUPTE, Ravindra, Dattatraya , TANNU, Aditi, Amol , PANICKER, Radha, Bhaskar , SHARMA, Somesh
- 申请人地址： Nicholas Piramal Tower Ganpatrao Kadam Marg, Lower Parel Mumbai 400 013 IN
- 专利权人： PIRAMAL LIFE SCIENCES LIMITED,GUPTE, Ravindra, Dattatraya,TANNU, Aditi, Amol,PANICKER, Radha, Bhaskar,SHARMA, Somesh
- 当前专利权人： PIRAMAL LIFE SCIENCES LIMITED,GUPTE, Ravindra, Dattatraya,TANNU, Aditi, Amol,PANICKER, Radha, Bhaskar,SHARMA, Somesh
- 当前专利权人地址： Nicholas Piramal Tower Ganpatrao Kadam Marg, Lower Parel Mumbai 400 013 IN
- 优先权： US60/920,445 20070327
- 主分类号： A01K67/027
- IPC分类号： A01K67/027
摘要：
The present invention relates to a method for evaluating a test compound for antithrombotic activity, thrombolytic activity, or a combination thereof. This method can include providing or employing a donor test animal and a recipient test animal. The donor and recipient test animals can have been pretreated with test compound. The donor test animal can be configured to provide oxygenated blood to the recipient test animal through a thrombus inducing system. This method also includes initiating transport of blood from the donor test animal to the recipient test animal through the thrombus inducing system. The method can include interrupting respiration of the recipient test animal and determining the length of time that the recipient test animal survives. In this method, a survival time longer than a predetermined threshold time indicates that the test compound has antithrombotic activity, thrombolytic activity, or a combination thereof.
摘要（中）：
本发明涉及评价抗血栓活性试验化合物，溶栓活性或其组合的方法。 该方法可以包括提供或使用供体测试动物和接受者测试动物。 供体和受体试验动物可以用试验化合物进行预处理。 供体测试动物可以被配置为通过血栓诱导系统向接受者测试动物提供氧合血液。 该方法还包括通过血栓诱导系统引发血液从供体测试动物运送到接受者测试动物。 该方法可以包括中断受体测试动物的呼吸并确定接受者测试动物存活的时间长短。 在该方法中，比预定阈值时间长的存活时间表明测试化合物具有抗血栓形成活性，溶栓活性或其组合。
IPC结构图谱:
| A | 人类生活必需 |
| --A01 | 农业；林业；畜牧业；狩猎；诱捕；捕鱼 |
| ----A01K | 畜牧业；禽类、鱼类、昆虫的管理；捕鱼；饲养或养殖其他类不包含的动物；动物的新品种 |
| ------A01K67/00 | 饲养或养殖其他类不包含的动物；动物新品种 |
| --------A01K67/027 | .脊椎动物的新品种 |