发明申请
WO2008106077A1 SUBSTITUTED BENZODIAZEPINONES, BENZOXAZEPINONES AND BENZOTHIAZEPINONES AS SODIUM CHANNEL BLOCKERS
审中-公开
基本信息:
- 专利标题： SUBSTITUTED BENZODIAZEPINONES, BENZOXAZEPINONES AND BENZOTHIAZEPINONES AS SODIUM CHANNEL BLOCKERS
- 专利标题（中）：作为钠通道阻断剂的取代苯并恶嗪酮，苯并恶唑酮和苯并噻唑酮
- 申请号：PCT/US2008/002441 申请日：2008-02-25
- 公开(公告)号：WO2008106077A1 公开(公告)日：2008-09-04
- 发明人： HOYT, Scott, B. , OK, Dong , OK, Hyun, O. , LONDON, Clare , DUFFY, Joseph, L.
- 申请人： MERCK & CO., INC. , HOYT, Scott, B. , OK, Dong , OK, Hyun, O. , LONDON, Clare , DUFFY, Joseph, L.
- 申请人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 专利权人： MERCK & CO., INC.,HOYT, Scott, B.,OK, Dong,OK, Hyun, O.,LONDON, Clare,DUFFY, Joseph, L.
- 当前专利权人： MERCK & CO., INC.,HOYT, Scott, B.,OK, Dong,OK, Hyun, O.,LONDON, Clare,DUFFY, Joseph, L.
- 当前专利权人地址： 126 East Lincoln Avenue Rahway, New Jersey 07065-0907 US
- 代理机构： MERCK & CO., INC.
- 优先权： US60/904,065 20070228
- 主分类号： A01N43/62
- IPC分类号： A01N43/62 ; A61K31/55
摘要：
The present invention is directed to substituted benzodiazepinones, benzoxazepinones and benzothiazepinones compounds that are sodium channel blockers useful for the treatment of chronic and neuropathic pain. The compounds of the present invention are also useful for the treatment of other conditions, including disorders of the CNS such as anxiety, depression, epilepsy, manic depression and bipolar disorder. This invention also provides pharmaceutical compositions comprising a compound of the present invention, either alone, or in combination with one or more therapeutically active compounds, and a pharmaceutically acceptable carrier. This invention further comprises methods for the treatment of acute pain, chronic pain, visceral pain, inflammatory pain, neuropathic pain and disorders of the CNS including, but not limited to, epilepsy, manic depression, depression, anxiety and bipolar disorder comprising administering the compounds and pharmaceutical compositions of the present invention.
摘要（中）：
本发明涉及用作治疗慢性和神经性疼痛的钠通道阻滞剂的取代苯并二氮杂酮，苯并氧氮杂酮和苯并噻唑酮化合物。 本发明的化合物还可用于治疗其他病症，包括CNS的疾病如焦虑症，抑郁症，癫痫症，躁狂抑郁症和双相性精神障碍。 本发明还提供包含单独的或与一种或多种治疗活性化合物组合的本发明化合物和药学上可接受的载体的药物组合物。 本发明还包括用于治疗急性疼痛，慢性疼痛，内脏痛，炎性疼痛，神经性疼痛和中枢神经系统疾病的方法，包括但不限于癫痫症，躁狂抑郁症，抑郁症，焦虑和双相情感障碍，包括给予化合物 和本发明的药物组合物。