发明申请
WO2008100463A1 3,4-DIHYDR0-L,4-BENZ0XAZINE, 3, 4-DIHYDR0-1, 4-BENZOTHIAZINE AND 1,2,3,4-TETRAHYDRO-QUINOXALINE DERIVATIVES AS ALPHA2C ADRENORECEPTOR AGONISTS
审中-公开
基本信息:
- 专利标题： 3,4-DIHYDR0-L,4-BENZ0XAZINE, 3, 4-DIHYDR0-1, 4-BENZOTHIAZINE AND 1,2,3,4-TETRAHYDRO-QUINOXALINE DERIVATIVES AS ALPHA2C ADRENORECEPTOR AGONISTS
- 专利标题（中）：3,4-DIHYDR0-L，4-BENZOXAZINE，3,4-DIHYDR0-1,4-BENZOTHIAZINE和1,2,3,4-四氢喹啉衍生物作为ALPHA2C ADRENORECEPTOR AGONISTS
- 申请号：PCT/US2008/001776 申请日：2008-02-11
- 公开(公告)号：WO2008100463A1 公开(公告)日：2008-08-21
- 发明人： MCCORMICK, Kevin, D. , BOYCE, Christopher, W. , SHIH, Neng-yang , ASLANIAN, Robert, G. , FEVRIER, Salem , MANGIARACINA, Pietro , DE LERA RUIZ, Manuel , YU, Younong , ZHENG, Junying , HUANG, Chia-yu , LIANG, Bo , LIU, Rong-Qiang , LIU, Ruiyan , GUISE ZAWACKI, Lisa
- 申请人： SCHERING CORPORATION , PHARMACOPEIA, INC. , MCCORMICK, Kevin, D. , BOYCE, Christopher, W. , SHIH, Neng-yang , ASLANIAN, Robert, G. , FEVRIER, Salem , MANGIARACINA, Pietro , DE LERA RUIZ, Manuel , YU, Younong , ZHENG, Junying , HUANG, Chia-yu , LIANG, Bo , LIU, Rong-Qiang , LIU, Ruiyan , GUISE ZAWACKI, Lisa
- 申请人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 专利权人： SCHERING CORPORATION,PHARMACOPEIA, INC.,MCCORMICK, Kevin, D.,BOYCE, Christopher, W.,SHIH, Neng-yang,ASLANIAN, Robert, G.,FEVRIER, Salem,MANGIARACINA, Pietro,DE LERA RUIZ, Manuel,YU, Younong,ZHENG, Junying,HUANG, Chia-yu,LIANG, Bo,LIU, Rong-Qiang,LIU, Ruiyan,GUISE ZAWACKI, Lisa
- 当前专利权人： SCHERING CORPORATION,PHARMACOPEIA, INC.,MCCORMICK, Kevin, D.,BOYCE, Christopher, W.,SHIH, Neng-yang,ASLANIAN, Robert, G.,FEVRIER, Salem,MANGIARACINA, Pietro,DE LERA RUIZ, Manuel,YU, Younong,ZHENG, Junying,HUANG, Chia-yu,LIANG, Bo,LIU, Rong-Qiang,LIU, Ruiyan,GUISE ZAWACKI, Lisa
- 当前专利权人地址： 2000 Galloping Hill Road Kenilworth, New Jersey 07033-0530 US
- 代理机构： RUSSELL, Mark, W.
- 优先权： US11/705,673 20070213
- 主分类号： A61K31/4985
- IPC分类号： A61K31/4985 ; A61K31/5383 ; A61K31/42 ; C07D403/06 ; C07D413/06 ; C07D413/14 ; C07D417/06 ; C07D471/04 ; C07D498/04 ; A61P11/02 ; A61P29/00 ; A61P25/24 ; A61P27/06
摘要：
The present invention relates to a novel class of phenylmorpholine and phenyl thiomorpholine compounds useful as alpha2C adrenergic receptor agonists, pharmaceutical compositions containing the compounds, and methods of treatment, prevention, inhibition,- or amelioration of one or more diseases associated with the alpha2C adrenergic receptor agonists, such as allergic rhinitis, congestion, pain, diarrhea, glaucoma, congestive heart failure, cardiac ischemia, manic disorders, depression, anxiety and schizophrenia.
摘要（中）：
本发明涉及可用作α2C肾上腺素能受体激动剂的新一类苯基吗啉和苯硫基吗啉化合物，含有该化合物的药物组合物，以及治疗，预防，抑制或改善与α2C肾上腺素能受体相关的一种或多种疾病的方法 激动剂如过敏性鼻炎，充血，疼痛，腹泻，青光眼，充血性心力衰竭，心脏缺血，躁狂症，抑郁，焦虑和精神分裂症。
IPC结构图谱:
| A | 人类生活必需 |
| --A61 | 医学或兽医学；卫生学 |
| ----A61K | 医用、牙科用或梳妆用的配制品 |
| ------A61K31/00 | 含有机有效成分的医药配制品 |
| --------A61K31/33 | .杂环化合物 |
| ----------A61K31/335 | ..仅有氧作为环杂原子的，例如制霉色基素 |
| ------------A61K31/40 | ...有仅以1个氮作为环杂原子的五元环的，例如舒必利、琥珀酰亚胺、托尔米丁、甲氧吡丁苯 |
| --------------A61K31/4985 | ....与杂环邻位或迫位稠合的吡嗪或哌嗪 |