基本信息:
- 专利标题： LIPIDS AND LIPID ASSEMBLIES COMPRISING TRANSFECTION ENHANCER ELEMENTS
- 专利标题（中）：包含转运增强元件的脂肪和脂肪组合物
- 申请号：PCT/EP2007/011187 申请日：2007-12-19
- 公开(公告)号：WO2008074487A2 公开(公告)日：2008-06-26
- 发明人： PANZNER, Steffen , LUTZ, Silke , SIEPI, Evgenios , REINSCH, Christian , MULLER, Claudia
- 申请人： NOVOSOM AG , PANZNER, Steffen , LUTZ, Silke , SIEPI, Evgenios , REINSCH, Christian , MULLER, Claudia
- 申请人地址： Weinbergweg 22 06120 Halle DE
- 专利权人： NOVOSOM AG,PANZNER, Steffen,LUTZ, Silke,SIEPI, Evgenios,REINSCH, Christian,MULLER, Claudia
- 当前专利权人： NOVOSOM AG,PANZNER, Steffen,LUTZ, Silke,SIEPI, Evgenios,REINSCH, Christian,MULLER, Claudia
- 当前专利权人地址： Weinbergweg 22 06120 Halle DE
- 代理机构： CRUMP, Julian, Richard, John et al.
- 优先权： EP06256450.5 20061219; US11/642.347 20061219; EP07117189.6 20070925
摘要：
Lipid assemblies, such as liposomes, comprising transfection enhancer elements (TEE's), which are complexed with the lipid assemblies by means of ionic interactions, or lipids incorporating such TEE's are disclosed for enhancing the fusogenicity of the lipid assemblies. The TEE's have the formula: hydrophobic moiety - pH sensitive hydrophilic moiety (II) The pH sensitive hydrophilic moiety of each TEE is a weak acid having a pka of between 2 and 6 or a zwitterionic structure comprising a combination of acidic groups with weak bases having a pKa of between 3 and 8. Lipids incorporating one or more such TEEs have the formula (I): Lipid moiety- [Hydrophobic moiety - pH sensitive hydrophilic moiety] (I).
摘要（中）：
公开了脂质体组合物，例如脂质体，其包含通过离子相互作用与脂质组合物复合的转染增强子元件（TEE）或掺入这种TEE的脂质，用于增强脂质组件的融合性。 TEE具有以下配方：疏水部分 - pH敏感的亲水部分（II）每个TEE的pH敏感的亲水部分是pka为2至6的弱酸或包含具有弱碱基的酸性基团的组合的两性离子结构， 含有一个或多个这样的TEE的脂质具有式（I）：脂质部分 - [疏水部分 - pH敏感的亲水部分]（I）。