发明申请
WO2008046598A1 DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR
审中-公开
基本信息:
- 专利标题： DERIVATIVES OF 4-(2-AMINO-1-HYDROXYETHYL)PHENOL AS AGONISTS OF THE β2 ADRENERGIC RECEPTOR
- 专利标题（中）：4-（2-氨基-1-羟基乙基）酚的衍生物作为β2受体受体的激动剂
- 申请号：PCT/EP2007/008992 申请日：2007-10-17
- 公开(公告)号：WO2008046598A1 公开(公告)日：2008-04-24
- 发明人： BACH TANA, Jordi , CRESPO CRESPO, Maria, Isabel , PUIG DURAN, Carlos , GUAL ROIG, Silvia , ORTEGA MUÑOZ, Albert
- 申请人： LABORATORIOS ALMIRALL, S.A. , BACH TANA, Jordi , CRESPO CRESPO, Maria, Isabel , PUIG DURAN, Carlos , GUAL ROIG, Silvia , ORTEGA MUÑOZ, Albert
- 申请人地址： Ronda del General Mitre, 151 E-08022 Barcelona ES
- 专利权人： LABORATORIOS ALMIRALL, S.A.,BACH TANA, Jordi,CRESPO CRESPO, Maria, Isabel,PUIG DURAN, Carlos,GUAL ROIG, Silvia,ORTEGA MUÑOZ, Albert
- 当前专利权人： LABORATORIOS ALMIRALL, S.A.,BACH TANA, Jordi,CRESPO CRESPO, Maria, Isabel,PUIG DURAN, Carlos,GUAL ROIG, Silvia,ORTEGA MUÑOZ, Albert
- 当前专利权人地址： Ronda del General Mitre, 151 E-08022 Barcelona ES
- 代理机构： SRINIVASAN, Ravi, Chandran et al.
- 优先权： ESP200602676 20061020
- 主分类号： C07D215/22
- IPC分类号： C07D215/22 ; C07C217/60 ; A61K31/435 ; A61K31/137 ; A61P9/00 ; A61P11/06 ; A61P29/00 ; A61P27/06
摘要：
The present invention provides a Compound of formula (I), wherein: R 1 is a group selected from -CH 2 OH,-NH(CO)H; and R 2 is a hydrogen atom; or R 1 together with R 2 form the group -NH-C(O)-CH=CH-, wherein the nitrogen atom is bound to the carbon atom in the phenyl ring holding R 1 and the carbon atom is bound to the carbon atom in the phenyl ring holding R 2 ; R 3a and R 3b are independently selected from the group consisting of hydrogen atoms and C 1-4 alkyl groups; X and Y are independently selected from the group consisting of direct bond and oxygen atom; n, m and q each independently has a value selected from 0, 1, 2 and 3; p has a value selected from 1, 2 and 3; R 4 and R 5 are independently selected from hydrogen atoms, halogen atoms, C 1-4 alkyl, C 1-4 alkoxy, -CONH 2 , -NHCONH 2 , -SR 7 , -SOR 7 , -SO 2 R 7 , -SO 2 NHR 8 and the groups (a) and (b), wherein R 7 is selected from C 1-4 alkyl and C 3-8 cycloalkyl and R 8 is selected from hydrogen atoms and C 1-4 alkyl groups; R 6 is selected from the group consisting of hydrogen atoms, halogen atoms, C 1-4 alkyl and C 1-4 alkoxy or a pharmaceutically-acceptable salt, solvate or stereoisomer thereof.
摘要（中）：
本发明提供式（I）的化合物，其中：R 1是选自-CH 2 OH，-NH（CO）H; R 2是氢原子; 或R 1与R 2一起形成基团-NH-C（O）-CH = CH-，其中氮原子与苯基中的碳原子结合 环保持R 1，并且碳原子与保持R 2的苯环中的碳原子结合; R 3a和 R 3b独立地选自氢原子和C 1-4烷基; X和Y独立地选自直接键和氧原子; n，m和q各自独立地具有选自0,1,2和3的值; p具有选自1,2和3的值; R 4和R 5独立地选自氢原子，卤素原子，C 1-4烷基，C 1-4烷基， 烷氧基，-CONH 2，-NHCONH 2，-SR 7，-SOR 7， - SO 2，N 2，NH 2，和（b），其中（a）和（b） R 7选自C 1-4烷基和C 3-8环烷基，R 8选自： 氢原子和C 1-4烷基; R 6选自氢原子，卤素原子，C 1-4烷基和C 1-4烷氧基或药学上可接受的盐 可接受的盐，溶剂合物或立体异构体。
IPC结构图谱:
| C | 化学；冶金 |
| --C07 | 有机化学 |
| ----C07D | 杂环化合物 |
| ------C07D215/00 | 杂环化合物，含喹啉或氢化喹啉环系 |
| --------C07D215/02 | .环氮原子和非环原子间无键或只有氢原子或碳原子直接连在环氮原子上 |
| ----------C07D215/04 | ..只有氢原子或仅含氢和碳原子的基直接连在环碳原子上 |
| ------------C07D215/20 | ...氧原子 |
| --------------C07D215/22 | ....连在位置2或4 |