基本信息:
- 专利标题: BIOAVAILABLE FUCOIDAN AND METHODS FOR PREPARING THE SAME
- 专利标题(中):生物福利药物及其制备方法
- 申请号:PCT/KR2007/004453 申请日:2007-09-14
- 公开(公告)号:WO2008041799A1 公开(公告)日:2008-04-10
- 发明人: JUNG, young Mi , KIM, Tae Kwon , PARK, Dong Chan , LEE, Yong Hyun
- 申请人: ENZ BIO CO., LTD. , JUNG, young Mi , KIM, Tae Kwon , PARK, Dong Chan , LEE, Yong Hyun
- 申请人地址: 507 Techno B/D, Kyungpook National University 573-13 Bokhyun-dong, Buk-gu Daegu 702-832 KR
- 专利权人: ENZ BIO CO., LTD.,JUNG, young Mi,KIM, Tae Kwon,PARK, Dong Chan,LEE, Yong Hyun
- 当前专利权人: ENZ BIO CO., LTD.,JUNG, young Mi,KIM, Tae Kwon,PARK, Dong Chan,LEE, Yong Hyun
- 当前专利权人地址: 507 Techno B/D, Kyungpook National University 573-13 Bokhyun-dong, Buk-gu Daegu 702-832 KR
- 代理机构: YANG, Boo-Hyun et al.
- 优先权: KR10-2006-0097392 20061002
- 主分类号: A23L1/325
- IPC分类号: A23L1/325
摘要:
The present invention relates to a bioavailable fucoidan characterized in that the bioavailable fucoidan has (a) 20-40% of the content of sulfate group; (b) 1,000-30,000 Da of the weight average molecular weight; (c) 1-6 of polydispersity; and (d) 0-200 centi-poise of viscosity. Since the low molecular weighted fucoidan of the present invention has higher content of sulfate groups, low weight average molecular weight of less than 30,000 Da, low polydispersity and viscosity, and high water-solubility, its absorption rate in the body is greatly increased resulting in high improvement in its bioavailability. Accordingly, it would be appreciated that the present low molecular weight fucoidan sufficiently exerts its unique physiological activities in the body (inhibition of cancer cell proliferation, anti-oxidative activities, suppression of blood glucose level, anticoagulant effects, suppression of triglyceride and cholesterol level, and improvement in the therapeutic effect to gastric ulcer). In addition, the improved physical properties of bioavailable fucoidans of this invention ensure to overcome problems owing to non- homogeneous quality in conventional fucoidan products.
摘要(中):
本发明涉及生物可利用的岩藻依聚糖,其特征在于生物可利用的岩藻依聚糖具有(a)硫酸根的含量的20-40% (b)1,000-30,000Da重均分子量; (c)多分散性1-6; 和(d)粘度为0-200厘泊。 由于本发明的低分子量岩藻依聚糖具有较高的硫酸基含量,重均分子量小于30,000Da,多分散性和粘度低,水溶性高,因此其体内的吸收率大大增加, 其生物利用度高度提高。 因此,应当理解,本发明的低分子量岩藻依聚糖在体内充分发挥其独特的生理活性(抑制癌细胞增殖,抗氧化活性,抑制血糖水平,抗凝血作用,抑制甘油三酯和胆固醇水平, 改善胃溃疡的治疗效果)。 此外,本发明的生物可利用的岩藻子聚糖的改进的物理性质确保了克服由于常规岩藻依聚糖产品质量非均质而引起的问题。