发明申请
WO2008008859A2 MACROMOLECULES MODIFIED WITH ELECTROPHILIC GROUPS AND METHODS OF MAKING AND USING THEREOF
审中-公开
基本信息:
- 专利标题： MACROMOLECULES MODIFIED WITH ELECTROPHILIC GROUPS AND METHODS OF MAKING AND USING THEREOF
- 专利标题（中）：用电子基团修饰的大分子微球及其制备和使用方法
- 申请号：PCT/US2007/073294 申请日：2007-07-11
- 公开(公告)号：WO2008008859A2 公开(公告)日：2008-01-17
- 发明人： PRESTWICH, Glenn, D. , SERBAN, Monica
- 申请人： UNIVERSITY OF UTAH RESEARCH FOUNDATION , PRESTWICH, Glenn, D. , SERBAN, Monica
- 申请人地址： 615 Arapeen Drive, Suite 310 Salt Lake City, UT 84108 US
- 专利权人： UNIVERSITY OF UTAH RESEARCH FOUNDATION,PRESTWICH, Glenn, D.,SERBAN, Monica
- 当前专利权人： UNIVERSITY OF UTAH RESEARCH FOUNDATION,PRESTWICH, Glenn, D.,SERBAN, Monica
- 当前专利权人地址： 615 Arapeen Drive, Suite 310 Salt Lake City, UT 84108 US
- 代理机构： NGUYEN, Sam, L. et al.
- 优先权： US60/806,966 20060711
- 主分类号： C08B37/08
- IPC分类号： C08B37/08
摘要：
Described herein are macromolecules modified with electrophilic groups and methods of making and using thereof. The preparation of a thiol-reactive, electrophililic derivative of HA in order to prepare "crosslinker-free" hydrogels are described as well as compounds and methods that are capable of coupling two or more molecules, such as macromolecules, under mild conditions. Specifically disclosed is the introduction of reactive bromo- and iodoacetate functionalities at the hydroxyl groups that are abundantly present on the HA polymer. The "crosslinker- free" hydrogels described have numerous applications including, but not limited to, drug delivery, small molecule delivery, wound healing, burn injury healing, tissue regeneration/engineering, cell culturing, and bio-artificial materials.
摘要（中）：
本文描述了用亲电子基团修饰的大分子及其制备和使用方法。 制备HA的硫醇反应性亲电子衍生物以制备“无交联剂” 描述了水凝胶以及能够在温和条件下偶联两种或更多种分子（例如大分子）的化合物和方法。 具体公开的是在HA聚合物上大量存在的羟基上引入反应性溴代和碘代乙酸酯官能团。 “无交联剂” 所描述的水凝胶具有许多应用，包括但不限于药物递送，小分子递送，伤口愈合，烧伤治愈，组织再生/工程化，细胞培养和生物人造材料。
IPC结构图谱:
| C | 化学；冶金 |
| --C08 | 有机高分子化合物；其制备或化学加工；以其为基料的组合物 |
| ----C08B | 多糖类；其衍生物 |
| ------C08B37/00 | 不包括在C08B1/00至C08B35/00组内的多糖类的制备；其衍生物 |
| --------C08B37/08 | .壳质多糖；硫酸软骨素；透明质酸；它们的衍生物 |